Mammary Gland Stem Cells and the Cells of Origin of Breast Cancers
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 3117
Special Issue Editors
2. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
Interests: breast cancer; cancer stem cells; molecular pathology; regulation of ubiquitination; animal models of cancer
2. Key Laboratory of Breast Cancer in Shanghai, The Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai 200032, China
3. The International Co-Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Interests: breast cancer; cancer stem cells
Special Issue Information
Dear Colleagues,
Mammary stem cells (MaSCs) play a key role in the development of breast and carcinogenesis. Mammary cancer stem cells (MaCSCs) are recognized as the root cause of breast cancer progression, recurrence, metastasis, and drug resistance. Accumulating studies have shown that malignant tumors are more likely to originate from the normal stem or progenitor cells, so the regulatory mechanisms in the breast normal stem cells are mostly retained in breast cancer stem cells; however, limited knowledge about the regulation in their self-renewal and difference has been revealed. This Special Issue will focus on diverse studies on origins, heterogeneity, and function of MaSCs and MaCSCs, and especially molecular mechanisms in regulating the self-renewal, differentiation, and transformation of MaSCs and MaCSCs. New technology-based research and preclinical models are also welcomed, such as single cell atlas, joint omics, patient-derived organoids, and animal models. This Special Issue calls for both reviews and original research.
Prof. Dr. Ceshi Chen
Prof. Dr. Suling Liu
Guest Editors
Manuscript Submission Information
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Keywords
- mammary development and lineage tracing
- mammary gland stem cells and breast cancer stem cells
- epithelial–mesenchymal transition during breast carcinogenesis
- new (stem) cell population in breast (cancer)
- patient-derived organoids and animal models
