Current Progress in Cerebrovascular Diseases

Dear Colleagues,

Cerebrovascular diseases represent a leading cause of death and disability worldwide, encompassing a broad spectrum of conditions such as ischemic stroke, hemorrhagic stroke, vascular dementia, intracranial aneurysm, arteriovenous malformation, and subarachnoid hemorrhage. These disorders arise from complex and dynamic interactions between the vascular, neural, and immune systems. While advances in prevention and acute clinical care have improved outcomes for some patients, the underlying mechanisms driving these diseases are still not fully understood.

Recent progress in imaging technologies, multi-omics approaches, and experimental disease models has opened up new avenues for investigating cerebrovascular pathology at the molecular, cellular, and systemic levels. Research is uncovering critical roles played by endothelial dysfunction, blood–brain barrier disruption, vascular remodeling, and inflammation. Nevertheless, several fundamental questions remain: What triggers rupture in intracranial aneurysms or arteriovenous malformation? How do systemic risk factors such as hypertension and diabetes interact with brain vasculature over time? What drives vascular contributions to cognitive decline and neurodegeneration? Which molecular pathways might be targeted to preserve cerebrovascular integrity or promote recovery after injury?

Our aim in launching this Special Issue, “Current Progress in Cerebrovascular Diseases”, is to highlight emerging discoveries and innovations across the field. We welcome original research and review articles that will advance our understanding of mechanisms, diagnostics, and therapeutic strategies in intracranial aneurysms, arteriovenous malformation, subarachnoid hemorrhage, and other cerebrovascular disorders.

Dr. Zhen Xu
Guest Editor

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