Colorectal Carcinoma: Pathologic Aspects and Treatment

Modern lifestyles have undoubtedly influenced the increase in the incidence of colorectal cancer (CRC) around the world. We are aware that this type of cancer not only has a genetic component, but is also a consequence of two fundamental factors, which are sedentary lifestyle and the abuse of processed foods high in salt and added sugars. Thus, the scientific community—conducting both basic and clinical research—is dedicating efforts to deepen our knowledge on the pathogenesis of this disease and to propose new treatments.

Genetic and environmental factors contribute to CRC development by promoting the acquisition of cancer hallmarks due to the accumulation of genetic and epigenetic mutations that activate oncogenes and inactivate tumor suppressor genes (Hanahan and Weinberg, 2011), which progressively affect various signaling pathways within colon epithelial cells. Different mechanisms of molecular progression by which CRC can develop have been defined. Ongoing research into the physiological aspects that lead to the development of colon cancer is relevant for finding appropriate, efficient and successful treatments.

The incidence of colon cancer occupies a worrying place in health statistics worldwide. Therefore, it is of paramount importance to publicize current advances in our knowledge of the disease, its spread and areas of opportunity to attack it. In this Special Issue, we encourage researchers to submit reviews or original articles on current advances in colon cancer treatment, future perspectives in personalized medicine and drug repositioning.

Dr. Nadia Judith Jacobo-Herrera
Guest Editor

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