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Cells
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Rickettsial Diseases: From Pathogenesis to Targeted Therapies
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Rickettsial Diseases: From Pathogenesis to Targeted Therapies

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1667

Special Issue Editor

Dr. Abha Sahni

E-Mail Website
Guest Editor
Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX, USA
Interests: intracellular bacteria; endothelium; infection; pathogenesis; host-pathogen interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Rickettsial organisms are intracellular alpha proteobacteria from the order Rickettsiales, which contains two families: Rickettsiaceae and Anaplasmataceae. Rickettsiaceae comprises two genera: Rickettsia and Orientia, while Anaplasmataceae consists of five genera: Ehrlichia, Anaplasma, Neorickettsia, Neoehrlichia, and Wolbachia. Coxiella burnetii was previously classified among Rickettsiales but has now been placed with g-proteobacteria.  These bacteria are transmitted by ectoparasites such as fleas, lice, mites, and ticks via bites or infectious fluids (such as feces) inoculated into host skin. Tickborne spotted fever rickettsioses are the most reported travel-associated rickettsial infections. Rickettsial pathogens cause some of the most severe and potentially life-threatening diseases. We would like to invite the submission of manuscripts covering every aspect of bacterial pathogenesis and host–pathogen interactions related to the rickettsial organisms. The aim of this Special Issue is to facilitate a compendium of novel ideas related to these microbial infections that cause various human diseases.

Dr. Abha Sahni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endothelium
  • tickborne diseases
  • host–pathogen interaction
  • bacterial pathogenesis

Published Papers (1 paper)

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Research

13 pages, 5659 KiB  
Article
Rickettsia Deregulates Genes Coding for the Neurotoxic Cell Response Pathways in Cerebrocortical Neurons In Vitro
by Martin Cente, Monika Danchenko, Ludovit Skultety, Peter Filipcik and Zuzana Sekeyova
Cells 2023, 12(9), 1235; https://doi.org/10.3390/cells12091235 - 25 Apr 2023
Viewed by 1363
Abstract
Rickettsial infections of the central nervous system (CNS) are manifested by severe neurological symptoms and represent a serious life-threatening condition. Despite the considerable health danger, only a few studies have been conducted focusing on the pathogenesis induced by Rickettsia sp. in CNS. To [...] Read more.
Rickettsial infections of the central nervous system (CNS) are manifested by severe neurological symptoms and represent a serious life-threatening condition. Despite the considerable health danger, only a few studies have been conducted focusing on the pathogenesis induced by Rickettsia sp. in CNS. To investigate the signaling pathways associated with the neurotoxic effects of rickettsiae, we employed an experimental model of cerebrocortical neurons combined with molecular profiling and comprehensive bioinformatic analysis. The cytopathic effect induced by Rickettsia akari and Rickettsia slovaca was demonstrated by decreased neuronal viability, structural changes in cell morphology, and extensive fragmentation of neurites in vitro. Targeted profiling revealed the deregulation of genes involved in the neuroinflammatory and neurotoxic cell response pathways. Although quantitative analysis showed differences in gene expression response, functional annotation revealed that the biological processes are largely shared between both Rickettsia species. The identified enriched pathways are associated with cytokine signaling, chemotaxis of immune cells, responses to infectious agents, interactions between neurons, endothelial and glial cells, and regulation of neuronal apoptotic processes. The findings of our study provide new insight into the etiopathogenesis of CNS infection and further expand the understanding of molecular signaling associated with neuroinvasive Rickettsia species. Full article
(This article belongs to the Special Issue Rickettsial Diseases: From Pathogenesis to Targeted Therapies)
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