Glycoproteomics and Protein Glycosylation in Cell Biology and Diseases

Dear Colleagues,

Most secretory and membrane-bound proteins produced by mammalian cells contain covalently linked glycans with diverse structures. They play a pivotal role in many biological processes, such as protein folding, cell adhesion and trafficking, cell signaling, pathogen recognition, and immune response. Glycan synthesis is not template bound but involves the concerted action of glycosidases, glycosyltransferases, and glycan-modifying enzymes. Environmental factors and immune pressure can lead to genetic and epigenetic modification of these enzymes and result in altered glycan biosynthesis and protein glycosylation, leading to abnormal biological conditions and various diseases, including cancer. Many disease biomarkers are glycoproteins or glycosylation assays. With the recent advances in glycoproteomics and other glyco-technology, studies ranging from interrogation of molecular mechanisms at cellular, organelle, and other subcellular levels to characterization of various clinical specimens for biomarker discovery have been driving many new discoveries and hypotheses in glycobiology and disease study. In this Special Issue, we welcome submissions of original research or review articles aiming at the broad field of glycobiology and glycoproteomics in studying the implication of protein glycosylation in cell biology and diseases.

Dr. Sheng Pan
Guest Editor

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