Epithelial-Immune Cell Interactions in Gut Homeostasis and Inflammation

Dear Colleagues,

The intestinal epithelium and mucosal immune system closely coordinate to sustain gut homeostasis and provide effective defenses against injury and infection. Epithelial cells serve as both a physical barrier and as dynamic communicators with various immune cell populations. This intricate epithelial–immune crosstalk preserves tissue health, regulates immune tolerance, and orchestrates protective responses against pathogens. The disruption of these interactions can result in barrier dysfunction, intestinal inflammation, dysbiosis, and disease, including inflammatory bowel disease and colorectal cancer. This Special Issue, “Epithelial-Immune Cell Interactions in Gut Homeostasis and Inflammation”, seeks to showcase emerging insights into the signaling pathways, immune crosstalk, and host–microbe interactions that define mucosal health and welcomes submissions that reveal their molecular and cellular mechanisms, the role of the gut microbiome, the effects of barrier breakdown, and the use of advanced models or technologies to investigate these networks. Reviews and perspectives on strategies that target epithelial–immune cell interactions for therapeutic benefit are also encouraged.

Dr. Neeraj Kapur
Guest Editor

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