Factors Involved in Structural and Functional Renal Impairments in Acute and Chronic Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 5289

Special Issue Editor


E-Mail Website
Guest Editor
Professor of Pathology, Department of Medical Education, School of Medicine, University of Texas (UTRGV), 1204 W Schunior Street, Edinburg, TX 78541, USA
Interests: pathomechanisms of renal injury; renal structural and functional
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Local cytotoxic effects, systemic disease burden, and nutritional imbalances are usually associated with the initiation and propagation of structural and functional renal impairments; irreversible chronic kidney diseases evolve without timely therapeutic interventions when available. Metabolic disorders, systemic diseases, infection, and immunoinflammatory dysregulations, including obesity, type 2 diabetes, hypertension, nephritis, and cystic diseases, are rising at an alarming rate around the globe and causing renal injuries, leading to significant worldwide morbidity and mortality. Despite progress in understanding the etiology of renal cell injuries, there are knowledge gaps on the pathogenesis of acute and chronic renal diseases. 

This Research Topic welcomes the submission of original manuscripts (unpublished research works), updated reviews (of the existing literate), and brief commentaries (on emerging areas of mechanisms of renal injuries). The idea is to broadly and holistically provide updated knowledge of structural and functional renal impairment mechanisms. Preliminary studies involving the effects of the ongoing pandemic or repeated vaccination on kidney structure and function are also welcome.

This Special Issue welcomes the clinical and basic science research submission of manuscripts related to:

  • Aging and kidney injury;
  • Diabetes and kidney injury;
  • Obesity and kidney injury;
  • Hypertension and kidney injury;
  • PKD and kidney injury;
  • Nephritis and kidney injury;
  • AKIs and kidney injury;
  • Ureteral reflux and kidney injury;
  • Pyelonephritis and kidney injury;
  • Tumor and kidney injury;
  • COVID-19 and kidney injury;
  • Nutrients/minerals and kidney injury;
  • Kidney as an endocrine organ.

Prof. Dr. Mohammed S. Razzaque
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes
  • obesity
  • hypertension
  • PKD
  • nephritis
  • AKIs
  • ureteral reflux
  • pyelonephritis
  • nutrients
  • COVID-19

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

23 pages, 648 KiB  
Review
Signaling Pathways of Podocyte Injury in Diabetic Kidney Disease and the Effect of Sodium-Glucose Cotransporter 2 Inhibitors
by Xiutian Chen, Jiali Wang, Yongda Lin, Yiping Liu and Tianbiao Zhou
Cells 2022, 11(23), 3913; https://doi.org/10.3390/cells11233913 - 3 Dec 2022
Cited by 16 | Viewed by 4362
Abstract
Diabetic kidney disease (DKD) is one of the most important comorbidities for patients with diabetes, and its incidence has exceeded one tenth, with an increasing trend. Studies have shown that diabetes is associated with a decrease in the number of podocytes. Diabetes can [...] Read more.
Diabetic kidney disease (DKD) is one of the most important comorbidities for patients with diabetes, and its incidence has exceeded one tenth, with an increasing trend. Studies have shown that diabetes is associated with a decrease in the number of podocytes. Diabetes can induce apoptosis of podocytes through several apoptotic pathways or induce autophagy of podocytes through related pathways. At the same time, hyperglycemia can also directly lead to apoptosis of podocytes, and the related inflammatory reactions are all harmful to podocytes. Podocyte damage is often accompanied by the production of proteinuria and the progression of DKD. As a new therapeutic agent for diabetes, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been demonstrated to be effective in the treatment of diabetes and the improvement of terminal outcomes in many rodent experiments and clinical studies. At the same time, SGLT2i can also play a protective role in diabetes-induced podocyte injury by improving the expression of nephrotic protein defects and inhibiting podocyte cytoskeletal remodeling. Some studies have also shown that SGLT2i can play a role in inhibiting the apoptosis and autophagy of cells. However, there is no relevant study that clearly indicates whether SGLT2i can also play a role in the above pathways in podocytes. This review mainly summarizes the damage to podocyte structure and function in DKD patients and related signaling pathways, as well as the possible protective mechanism of SGLT2i on podocyte function. Full article
Show Figures

Figure 1

Back to TopTop