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Cells
Special Issues
Cerebellar Development: From Cell Imaging to Clinical Applications
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Cerebellar Development: From Cell Imaging to Clinical Applications

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 3105

Special Issue Editors

Prof. Dr. Freek E. Hoebeek

E-Mail Website
Guest Editor
Department for Developmental Origins of Disease, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Interests: cerebellum; thalamus; circuit maturation; epilepsy; early life brain damage
Special Issues, Collections and Topics in MDPI journals
Dr. Jeroen Dudink

E-Mail Website
Guest Editor
Department of Neonatology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Interests: neonatal neurobehavior; sleep; cerebellum; neuromonitoring; neuroimaging

Special Issue Information

Dear Colleagues,

This Special Issue, “Cerebellar Development: From Cell Imaging to Clinical Applications”, will be a comprehensive collection of articles that provide an in-depth exploration of the development of the cerebellum, from early embryonic stages to adult function. The Issue will cover a range of topics, from the cellular and molecular mechanisms that regulate cerebellar development to the clinical applications of this knowledge in the diagnosis and treatment of neurodevelopmental and neurodegenerative disorders. Some of the articles will focus on the clinical applications of cerebellar development research, including the diagnosis and treatment of cerebellar ataxia and other neurodevelopmental disorders. The Issue will also explore the relationship between cerebellar development and autism spectrum disorders, as well as the pathogenesis and therapeutic approaches for neurodegenerative disorders of the cerebellum. This Special Issue will be a valuable resource for researchers, clinicians, and students interested in the developmental neurobiology of the cerebellum and its clinical implications. The Issue will provide a comprehensive and up-to-date account of the latest research in this field, including cutting-edge techniques in cell imaging, molecular biology, and genetics.

Prof. Dr. Freek E. Hoebeek
Dr. Jeroen Dudink
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • embryonic development of the cerebellum: from neurogenesis to neuronal migration
  • synaptic connectivity in the developing cerebellum: insights from cell imaging
  • the role of glia in cerebellar development and function
  • sleep and the developing cerebellum
  • neonatal cerebral injury
  • transcriptional regulation of cerebellar development
  • epigenetic mechanisms in cerebellar development and disease
  • neurodegenerative disorders of the cerebellum: pathogenesis and therapeutic approaches
  • cerebellar circuit development: from developmental neurobiology to clinical applications
  • cerebellar ataxia: insights into pathogenesis and diagnosis
  • cerebellar development and autism spectrum disorders
  • the role of non-coding RNAs in cerebellar development and function

Published Papers (2 papers)

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15 pages, 4633 KiB  
Article
Tracking of Internal Granular Progenitors Responding to Valproic Acid in the Cerebellar Cortex of Infant Ferrets
by Shiori Kamiya, Tetsuya Kobayashi and Kazuhiko Sawada
Cells 2024, 13(4), 308; https://doi.org/10.3390/cells13040308 - 7 Feb 2024
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Abstract
Internal granular progenitors (IGPs) in the developing cerebellar cortex of ferrets differentiate towards neural and glial lineages. The present study tracked IGPs that proliferated in response to valproic acid (VPA) to determine their fate during cerebellar cortical histogenesis. Ferret kits were used to [...] Read more.
Internal granular progenitors (IGPs) in the developing cerebellar cortex of ferrets differentiate towards neural and glial lineages. The present study tracked IGPs that proliferated in response to valproic acid (VPA) to determine their fate during cerebellar cortical histogenesis. Ferret kits were used to administer VPA (200 μg/g body weight) on postnatal days 6 and 7. EdU and BrdU were injected on postnatal days 5 and 7, respectively, to label the post-proliferative and proliferating cells when exposed to VPA. At postnatal day 20, when the external granule layer was most expanded, EdU- and BrdU-single-labeled cells were significantly denser in the inner granular layer of VPA-exposed ferrets than in controls. No EdU- or BrdU-labeling was found in Purkinje cells and molecular layer interneurons. Significantly higher percentages of NeuN and Pax6 immunostaining in VPA-exposed ferrets revealed VPA-induced differentiation of IGPs towards granular neurons in BrdU-single-labeled cells. In contrast, both EdU- and BrdU-single-labeled cells exhibited significantly greater percentages of PCNA immunostaining, which appeared in immature Bergman glia, in the internal granular layer of VPA-exposed ferrets. These findings suggest that VPA affects the proliferation of IGPs to induce differentiative division towards granular neurons as well as post-proliferative IGPs toward differentiation into Bergmann glia. Full article
(This article belongs to the Special Issue Cerebellar Development: From Cell Imaging to Clinical Applications)
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14 pages, 3285 KiB  
Article
Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex
by Margarita Belem Santana-Bejarano, Paula Romina Grosso-Martínez, Ana Graciela Puebla-Mora, María Guadalupe Martínez-Silva, Mario Nava-Villalba, Ana Laura Márquez-Aguirre, Daniel Ortuño-Sahagún and Marisol Godínez-Rubí
Cells 2023, 12(13), 1733; https://doi.org/10.3390/cells12131733 - 27 Jun 2023
Viewed by 1969
Abstract
During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species. PTN signaling includes PTPRZ1, ALK, and NRP-1 receptors, which are implicated in cell [...] Read more.
During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species. PTN signaling includes PTPRZ1, ALK, and NRP-1 receptors, which are implicated in cell differentiation, migration, and proliferation. However, its involvement in human cerebellar development has not been described so far. Therefore, we investigated whether PTN and its receptors were expressed in the human cerebellar cortex during fetal and early neonatal development. The expression profile of PTN and its receptors was analyzed using an immunohistochemical method. PTN, PTPRZ1, and NRP-1 were expressed from week 17 to the postnatal stage, with variable expression among granule cell precursors, glial cells, and Purkinje cells. ALK was only expressed during week 31. These results suggest that, in the fetal and neonatal human cerebellum, PTN is involved in cell communication through granule cell precursors, Bergmann glia, and Purkinje cells via PTPRZ1, NRP-1, and ALK signaling. This communication could be involved in cell proliferation and cellular migration. Overall, the present study represents the first characterization of PTN, PTPRZ1, ALK, and NRP-1 expression in human tissues, suggesting their involvement in cerebellar cortex development. Full article
(This article belongs to the Special Issue Cerebellar Development: From Cell Imaging to Clinical Applications)
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