Targeting Interleukins Series: Interleukin-1 in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 3014
Special Issue Editor
Special Issue Information
Dear Colleagues,
The interleukin-1 (IL-1) family includes 11 cytokines and 10 receptors, where IL-1a, IL-1b, IL-1Ra, and their receptor, IL-1R1, are the most well characterized. As part of the healthy host defense, IL-1 mediates the innate immune response against tissue infection and injury caused by chemical and environmental stimuli or microbes. Damage-associated molecular pattern (DAMP) and pathogen-associated molecular pattern (PAMP) signaling caused by injury and infection, respectively, lead to IL-1 gene transcription, proteolytic cleavage, and activation. IL-1 signaling at the infection site recruits and/or activates immune, epithelial, endothelial, and fibroblast cells to facilitate tissue clearance of microbes and damaged cells and mediate tissue repair. However, mutations or polymorphism in IL-1 or IL-1 regulators or chronic injury or infection lead to elevated or chronic IL-1 signaling that underlies inflammatory, autoimmune, malignant, and metabolic diseases. For example, normal IL-1 functions, including reactive oxygen production or the induction of VEGF secretion, are exploited by malignant cells in an inflammatory tumor microenvironment to promote disease progression. The role of IL-1 in disease is broad and complex, leading to the need for the development of multiple different IL-1 inhibitors that directly target IL-1 cytokines, IL-1 receptors, or IL-1 regulators. FDA-approved and investigational IL-1 inhibitors have been effective at alleviating symptoms of IL-1-triggered disease, emphasizing the culpability of IL-1 in disease initiation and progression.
This Special Edition on IL-1 in health and disease will report on the latest investigations into the mechanisms of IL-1 pathology and the latest (pre)clinical studies on the efficacy of IL-1 inhibitors in human disease.
Dr. Nikki Delk
Guest Editor
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Keywords
- interleukin-1
- IL-1
- human disease
- inflammation
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