Metallodrugs against Cancer Cells: Mechanisms of Action and Molecular Targets
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1193
Special Issue Editors
Interests: gastroenterology; intestine; intestinal microbiota; intestinal inflammation; TLR signaling; serotoninergic system; intestinal motility; colon cancer; metallodrugs; nanomolecules
Special Issues, Collections and Topics in MDPI journals
Interests: organometallic synthesis; cell biology; bioinorganic chemistry; cancer research; oxidative stress assays; cytotoxicity; primary cell culture; colon cancer
Special Issue Information
Dear Colleagues,
Many years of research have been conducted since the discovery of cisplatin- and platinum-based drugs as chemotherapists. Currently, research into new therapies for colon cancer based on new selective metallic compounds that act on new mechanisms of action and have fewer side effects is of great scientific interest. In these terms, there are several proteins or biomolecules specifically overexpressed in most human tumors that can be used as targets for metallodrugs. These cancer-related proteins play roles in inhibiting metastasis, angiogenesis, and proliferation. For these reasons, metallodrugs are interesting and promising in the next steps of antitumor therapy.
Metal complexes represent a huge field to explore thanks to their great versatility and different chemistry. Therefore, by changing a small moiety of the complex, the interaction with the molecular target can be changed drastically and, consequently, so can the mechanism of action and cell death. Additionally, some properties such as thermal behavior, optical properties and photostability could also improve the selectivity towards tumor cells.
This Special Issue of Cells, entitled “Metallodrugs against Cancer Cells: Mechanisms of Action and Molecular Targets”, welcomes original research articles focusing on the aspects of design and characterization of new metallodrugs that target new molecular mechanisms of cancer biology in order to improve the therapy and/or diagnosis of cancer.
Dr. Laura Grasa
Dr. Elisa Abás
Guest Editors
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Keywords
- cell death
- cytotoxicity
- molecular mechanism
- cell imaging
- theragnostic
- photodynamic therapy
- chemotherapy
- gene expression
- drug uptake
- SAR studies
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