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Cells
Special Issues
Brain Tumors: From Neuropathology to Molecular Biology
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Brain Tumors: From Neuropathology to Molecular Biology

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 2638

Special Issue Editors

Prof. Dr. Francesco Maiuri

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Guest Editor
Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Naples, Italy
Interests: neurosurgery; neuro-oncology; neuropathology
Special Issues, Collections and Topics in MDPI journals
Dr. Marialaura Del Basso De Caro

E-Mail Website
Guest Editor
Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Interests: neuropathology; neuro-oncology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Lorenzo Chiariotti

E-Mail Website
Guest Editor
Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples “Federico II”, 80131 Naples, Italy
Interests: tumor epigenetics; brain tumors; molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The classification of brain tumors has recently undergone several changes, primarily due to the identification of new histologic variants and the adoption of novel technologies. Up to several years ago, diagnosis was primarily performed on the basis of histopathological aspect of tumors and several immunohistochemical studies. In the 2016 WHO classification, and even more in the 2021 classification, thanks to the improved understanding of the genetic basis of tumorigenesis, the 2016 and 2021 WHO classifications were able to incorporate molecular findings into brain tumor diagnosis. The use of integrated phenotypic and genotypic parameters, provided by histology and molecular genetics, has provided greater accuracy to diagnosis, patient management, prognosis and treatment response.

Besides, in patients with similar neuropathological findings, the biomolecular studies have defined subgroups with different biomolecular features and different biological behaviors, response to treatment, recurrence rates and survivals. This Issue aims to discuss the improvements in tumor diagnosis and management enabled by biomolecular studies and neuropathology.

Prof. Dr. Francesco Maiuri
Prof. Dr. Marialaura Del Basso De Caro
Prof. Dr. Lorenzo Chiariotti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain tumor pathology
  • neuro-oncology
  • molecular biology
  • immunohistochemistry
  • histopathology

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Published Papers (1 paper)

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17 pages, 2118 KiB  
Systematic Review
The Three Pillars of Glioblastoma: A Systematic Review and Novel Analysis of Multi-Omics and Clinical Data
by Ciro De Luca, Assunta Virtuoso, Michele Papa, Giovanni Cirillo, Giuseppe La Rocca, Sergio Corvino, Manlio Barbarisi and Roberto Altieri
Cells 2024, 13(21), 1754; https://doi.org/10.3390/cells13211754 - 23 Oct 2024
Cited by 1 | Viewed by 2054
Abstract
Glioblastoma is the most fatal and common malignant brain tumor, excluding metastasis and with a median survival of approximately one year. While solid tumors benefit from newly approved drugs, immunotherapy, and prevention, none of these scenarios are opening for glioblastoma. The key to [...] Read more.
Glioblastoma is the most fatal and common malignant brain tumor, excluding metastasis and with a median survival of approximately one year. While solid tumors benefit from newly approved drugs, immunotherapy, and prevention, none of these scenarios are opening for glioblastoma. The key to unlocking the peculiar features of glioblastoma is observing its molecular and anatomical features tightly entangled with the host’s central nervous system (CNS). In June 2024, we searched the PUBMED electronic database. Data collection and analysis were conducted independently by two reviewers. Results: A total of 215 articles were identified, and 192 were excluded based on inclusion and exclusion criteria. The remaining 23 were used for collecting divergent molecular pathways and anatomical features of glioblastoma. The analysis of the selected papers revealed a multifaced tumor with extreme variability and cellular reprogramming that are observable within the same patient. All the variability of glioblastoma could be clustered into three pillars to dissect the physiology of the tumor: 1. necrotic core; 2. vascular proliferation; 3. CNS infiltration. These three pillars support glioblastoma survival, with a pivotal role of the neurovascular unit, as supported by the most recent paper published by experts in the field. Full article
(This article belongs to the Special Issue Brain Tumors: From Neuropathology to Molecular Biology)
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