Mitochondrial Dysfunction in Neurological Disorders: Molecular Mechanisms and Potential Points for Intervention

Dear Colleagues,

Mitochondria play a major role in the regulation of cellular bioenergetics as well as various non-energetic processes, like cell death mechanisms, generation of free radicals and antioxidative defense, immune response, and regulation of calcium homeostasis. Therefore, abnormal mitochondria signaling may be an important link between various disease-associated factors common to, and critical in, different central nervous system (CNS) diseases: from neurodevelopmental disorders, that occur early in life and persist until adulthood, to age-related neurodegenerative diseases. Understanding the exact position of mitochondrial dysfunction in the deleterious feed-forward loop critical for the development and progression of CNS diseases may help design successful therapeutic strategies for several fatal syndromes.

In this Special Issue, we cordially invite you to contribute, either in the form of original research articles, or reviews on all aspects related to the topic, describing mechanistic, functional, cellular, biochemical, or general aspects of mitochondrial dysfunction in neurological disorders. Relevant topics include, but are not limited to:

• Ageing
• Maternal immune activation
• Epigenetic factors
• Misfolded protein spread
• Glial pathology
• Inflammation
• In vitro and in vivo models
• Microbiota
• Diagnostics
• Bioimaging
• Translational medicine

Dr. Anna Wilkaniec
Dr. Agata Adamczyk
Guest Editors

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