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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Omics Data for Cancer Therapies: From Molecular Profiling to Clinical Applications

edited by

Luciano Cascione

submission deadline 31 Oct 2026 | 1 articles | Viewed by 895 | Submission Open

Keywords: multi-omics integration; precision oncology; biomarker discovery; computational oncology; translational cancer research

(This special issue belongs to the Section Cancer Informatics and Big Data)

Clinical Research in Gynecological Cancers

edited by

Federica Perelli

submission deadline 31 Oct 2026 | 2 articles | Viewed by 876 | Submission Open

Keywords: gynecologic oncology; hereditary cancer syndrome; BRCA mutation; gynecologic surgery; gynecologic ultrasound; gynecologic oncology prevention; molecular biomarkers; minimally invasive surgery; STIC (serous tubal intraepithelial carcinoma); ovarian cancer; fertility-sparing surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Biomarkers in the Management of Lung Cancer

edited by Ole Hilberg

submission deadline 31 Oct 2026 | 1 articles | Viewed by 860 | Submission Open

Keywords: lung cancer; biomarker; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Metabolic Reprogramming in Cancer: Implications for Tumor Progression, Metastasis, Immune Evasion and Therapy Resistance

edited by

Vasudevarao Penugurti

and Bramanandam Manavathi

submission deadline 31 Oct 2026 | Viewed by 751 | Submission Open

Keywords: cancer and mitochondrial metabolism; metabolic reprogramming; glutamine metabolism; tumor microenvironment; metabolic plasticity; oxidative phosphorylation; drug resistance; immune evasion; cancer metastasis; therapeutic metabolic targeting

(This special issue belongs to the Section Molecular Cancer Biology)

Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities

edited by

Michele Zanoni

, Giacomo Miserocchi and

Tania Rossi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 742 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; tumor–stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models

(This special issue belongs to the Section Tumor Microenvironment)

Novel Diagnostic and Therapeutic Approaches in Hepato-Pancreato-Biliary Cancer

edited by

Timothy M. Pawlik

submission deadline 31 Oct 2026 | 1 articles | Viewed by 731 | Submission Open

Keywords: cholangiocarcinoma; intrahepatic; resection; targeted therapy; chemotherapy; outcomes

(This special issue belongs to the Section Cancer Therapy)

Oral Potentially Malignant Disorders and Oral Cavity Cancer: 2nd Edition

edited by

I-Ta Lee

submission deadline 31 Oct 2026 | 1 articles | Viewed by 729 | Submission Open

Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine

(This special issue belongs to the Section Cancer Therapy)

Current Treatment Options for Rectal Cancer

edited by Jesús Pedro Paredes Cotoré

submission deadline 31 Oct 2026 | 1 articles | Viewed by 727 | Submission Open

Keywords: rectal cancer; therapeutic approach; rectal surgery; neoadjuvant treatment; radiotherapy; immunotherapy; chemotherapy; quality of life

(This special issue belongs to the Section Cancer Therapy)

Molecular Imaging in Oncology: Recent Advances (2nd Edition)

edited by

Lioe-Fee de Geus-Oei

submission deadline 31 Oct 2026 | 1 articles | Viewed by 720 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry

(This special issue belongs to the Section Cancer Therapy)

Pathological and Molecular Insights into Urothelial Carcinoma

edited by Gabriela M. Quiroga-Garza,

Maedeh Mohebnasab

and Dimitrios Korentzelos

submission deadline 31 Oct 2026 | 1 articles | Viewed by 653 | Submission Open

Keywords: bladder cancer; urothelial carcinoma; diagnosis; histopathology; molecular; genomics; biomarkers; prognosis; immunotherapy

The Development and Application of Imaging Biomarkers in Cancer: 2nd Edition

edited by

Abhishek Mahajan

submission deadline 31 Oct 2026 | 1 articles | Viewed by 637 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Advances in Skull Base Tumor Surgery: From Diagnosis to Minimally Invasive Treatment

edited by James P Chandler and

Ahmad Pour Rashidi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 622 | Submission Open

Keywords: skull base tumors; minimally invasive neurosurgery; advanced imaging; molecular diagnostics; cranial base reconstruction; targeted therapies; radiosurgery; precision medicine

(This special issue belongs to the Section Clinical Research in Cancer)

The Role of Nutrients in Cancer Progression

edited by

Ikuko Kato

submission deadline 31 Oct 2026 | Viewed by 564 | Submission Open

Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Pathophysiology)

Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy

edited by

Masaharu Seno

and

Mary J.C. Hendrix

submission deadline 31 Oct 2026 | Viewed by 535 | Submission Open

Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial–mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft

(This special issue belongs to the Section Cancer Therapy)

Nutritional Strategies Across the Cancer Continuum: Prevention, Therapeutic Intervention, Support, and Survivorship

edited by

Ananya Gupta

submission deadline 31 Oct 2026 | 1 articles | Viewed by 500 | Submission Open

Keywords: cancer prevention; clinical nutrition; malnutrition and cachexia; sarcopenia and nutrition; dietary patterns as cancer therapy; treatment-related sensory changes; cancer survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Surgical Treatment of Oral Cancer

edited by Zhigang Cai and

Shang Xie

submission deadline 31 Oct 2026 | Viewed by 472 | Submission Open

Keywords: oral cancer; surgical treatment; neck dissection; reconstructive surgery; free flap; transoral robotic surgery (TORS); complications; salvage surgery; quality of life; multidisciplinary management

(This special issue belongs to the Section Cancer Therapy)

Clinical Benefit of Hybrid PET/MRI Molecular Imaging in Oncology

edited by Ana María García-Vicente and

Edel Noriega-Álvarez

submission deadline 31 Oct 2026 | Viewed by 460 | Submission Open

Keywords: PET/MRI; hybrid imaging; gynecological cancer; prostate cancer; glioma; brain metastases; brain meningioma; sarcoma; liver cancer; hepato-biliary cancer; pancreatic cancer; rectal cancer; breast cancer

(This special issue belongs to the Section Clinical Research in Cancer)

Targeted and Translational Therapies in Genitourinary Cancers: Addressing Unmet Clinical Needs Through Organ-Specific Innovation

edited by

Akash Sabarwal

and

Saba Tabasum

submission deadline 31 Oct 2026 | Viewed by 442 | Submission Open

Keywords: genitourinary cancer; therapeutic resistance; precision oncology; biomarker-guided therapy; antibody-drug conjugates; prostate cancer; renal cell carcinoma; bladder cancer; testicular cancer; novel modalities; organ-specific strategies

(This special issue belongs to the Section Cancer Therapy)

Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes

edited by

Gabriela Ilie

submission deadline 31 Oct 2026 | Viewed by 432 | Submission Open

Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Signaling Networks and Systems Biology in Cancer

edited by

Rajesh Singh

and

Abhinava K. Mishra

submission deadline 31 Oct 2026 | Viewed by 426 | Submission Open

Keywords: cancer signaling; immuno-oncology; cancer nanotechnology; AI/ML in cancer; systems oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Non-Pharmacological Interventions in Oncology Supportive and Palliative Care

edited by

Leila Kozak

submission deadline 31 Oct 2026 | Viewed by 417 | Submission Open

Keywords: integrative palliative care; integrative therapies; non-pharmacological therapies; symptom management; palliative care; supportive care; massage; acupuncture; tai chi; virtual reality

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)

edited by

Claudia Peitzsch

and

Ina Kurth

submission deadline 31 Oct 2026 | Viewed by 416 | Submission Open

Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance

(This special issue belongs to the Section Cancer Therapy)

Opportunities and Challenges for Effective Cancer Immunotherapies

edited by

Gao Zhang

submission deadline 31 Oct 2026 | Viewed by 367 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; cellular therapy; tumor microenvironment; therapeutic resistance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Circulating Tumor Cells (CTCs) for Cancer Diagnosis and Prognosis

edited by

Athina N. Markou

submission deadline 31 Oct 2026 | Viewed by 357 | Submission Open

Keywords: CTCs; liquid biopsy; metastasis; biomarkers

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Targeting the Hypoxic Axis: HIF Signaling and Therapeutic Resistance in the Tumor Microenvironment

edited by

Bassam Janji

and

Ruize Gao

submission deadline 31 Oct 2026 | Viewed by 344 | Submission Open

Keywords: hypoxia-inducible factors (HIFs); tumor microenvironment; hypoxia signaling; therapeutic resistance; cancer metabolism; angiogenesis; immune evasion; targeted cancer therapy

(This special issue belongs to the Section Tumor Microenvironment)

Oxidative Stress in Cancer: From Mechanisms to Therapeutic Strategies

edited by

Francesco Marotta

and

Reza Rastmanesh

submission deadline 31 Oct 2026 | Viewed by 344 | Submission Open

Keywords: redox signaling; tumor microenvironment; senolytics; immunometabolism; gut microbiome; preventive oncology; drug delivery

(This special issue belongs to the Section Cancer Therapy)

Genetic Disorders and Cancer Susceptibility: Molecular Mechanisms, Risk Assessment and Targeted Therapies

edited by Silmara de Lima

submission deadline 31 Oct 2026 | Viewed by 340 | Submission Open

Keywords: neurofibromatosis type-1; optic pathway glioma; retinal ganglion cell survival; myelination; vision loss; targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Sarcoma Biology and Therapeutics: From Mechanisms to Novel Treatments

edited by

Margherita Cortini

submission deadline 31 Oct 2026 | Viewed by 325 | Submission Open

Keywords: sarcoma; bone and soft tissue sarcoma; tumor biology; molecular mechanisms; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening

Radiotherapy and the Tumor Microenvironment: From Basic Mechanisms to Clinical Translation

edited by Eleanor J. Cheadle and

Jamie Honeychurch

submission deadline 31 Oct 2026 | Viewed by 322 | Submission Open

Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma; immunogenic cell death

Skin and Hair Side Effects of Cancer Treatment

edited by Ian W. Tattersall

submission deadline 31 Oct 2026 | Viewed by 320 | Submission Open

Keywords: oncodermatology; toxicity management; supportive oncology

(This special issue belongs to the Section Cancer Therapy)

Local, Systemic and Combined Therapy for Hepatocellular Carcinoma

edited by Xiaoqun Dong

submission deadline 31 Oct 2026 | Viewed by 311 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research

(This special issue belongs to the Section Cancer Therapy)

Molecular Therapy Targets of Uterine and Ovarian Cancer

edited by Salvatore Lopez and

Fabian Kraus

submission deadline 31 Oct 2026 | Viewed by 308 | Submission Open

Keywords: endometrial cancer; ovarian cancer; molecular targets; immunotherapy; PARP inhibitor resistance; HER2-targeted therapy; biomarkers; CDK4/6 inhibition; tumor microenvironment; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Novel Agents and Treatments in Leiomyosarcoma

edited by

Elise F. Nassif Haddad

and Roberta Sanfilippo

submission deadline 31 Oct 2026 | Viewed by 305 | Submission Open

Keywords: leiomyosarcoma; uterine leiomyosarcoma; STUMP; retroperitoneal leiomyosarcoma; targeted therapies; precision medicine; immunotherapy; drug development; clinical trials; translational oncology

The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition

edited by

Roberto Tamma

submission deadline 31 Oct 2026 | Viewed by 299 | Submission Open

Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies

(This special issue belongs to the Section Tumor Microenvironment)

Epigenetic Modifications as Biomarkers of Tumor Development

edited by

Chenkai Ma

submission deadline 31 Oct 2026 | Viewed by 290 | Submission Open

Keywords: DNA Methylation; histone acetylation; liquid biopsies; oncogenesis; chromatin remodeling; early detection biomarkers; precision oncology; pharmaco-epigenetics

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Radiation Therapy for Head and Neck Cancer: 2nd Edition

edited by

Vassilis Kouloulias

submission deadline 31 Oct 2026 | Viewed by 280 | Submission Open

Keywords: adaptive radiotherapy; hyper- and hypo-fractionated radiotherapy; artificial intelligence in radiotherapy for head and neck cancer; quality assurance and set-up errors associated with IMRT, VMAT, IGRT, and SGRT techniques; protons and heavy ions for radiotherapy; re-irradiation; nanoparticles plus radiotherapy; hyperthermia plus radiotherapy; radiotherapy plus immunotherapy; the de-escalation of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma (2nd Edition)

edited by

Francesco E. Boccalatte

submission deadline 31 Oct 2026 | Viewed by 279 | Submission Open

Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation

(This special issue belongs to the Section Cancer Therapy)

Advancing Novel Cancer Therapeutics: Discovery, Validation and Translation of Molecular Targets

edited by Chandan Narayan and

A. R. M. Ruhul Amin

submission deadline 31 Oct 2026 | Viewed by 275 | Submission Open

Keywords: cancer therapeutics; precision medicine; aptamers; chimeric antigen receptor T cell therapy (CAR-T); CRISPR-Cas systems; AI

(This special issue belongs to the Section Cancer Therapy)

Innovations in Imaging and Endoscopic Diagnosis of Esophageal Cancer: From Early Detection to Clinical Decision Support

edited by

Hsiang-Chen Wang

Riya Karmakar

and Mahendra Bhatu Gawali

submission deadline 31 Oct 2026 | Viewed by 273 | Submission Open

Keywords: esophageal cancer; endoscopic imaging; early detection; image-enhanced endoscopy; optical imaging; artificial intelligence; computer-aided diagnosis; multimodal imaging; risk stratification; clinical decision support systems

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Immune Therapies for Hematological Malignancies

edited by Mohammad S. Hossain

submission deadline 31 Oct 2026 | Viewed by 268 | Submission Open

Keywords: hematological malignancies; immunotherapy; bone marrow transplantation; graft-versus-host disease (GVHD); CAR T-cell therapy; immune checkpoint inhibitors; bispecific monoclonal antibodies; cytomegalovirus (CMV) infection; antigen–antibody interactions

(This special issue belongs to the Section Cancer Therapy)

Artificial Intelligence in Cancer Prevention and Control

edited by Syed Nabeel Zafar

submission deadline 31 Oct 2026 | Viewed by 246 | Submission Open

Keywords: artificial intelligence; machine learning; cancer continuum; low-resource settings; health equity; low- and middle-income countries; global health; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Computational Multi-Omics in Liquid Biopsy: Integrating Tumor and Immune Signals for Precision Oncology

edited by

Giovanni Crisafulli

submission deadline 31 Oct 2026 | Viewed by 237 | Submission Open

Keywords: liquid biopsy; minimal residual disease (MRD); circulating tumor DNA (ctDNA); immunogenomics; tumor evolution; ultra-low frequency variant detection; computational oncology; error modeling and noise suppression; clonal hematopoiesis; longitudinal molecular monitoring; tumor/immune system coevolution

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Prevention, Diagnosis, and Therapy for Cervical and Vulvar Cancer

edited by

Dirk Michael Forner

submission deadline 31 Oct 2026 | Viewed by 221 | Submission Open

Keywords: vulvar carcinoma; cervical intraepithelial neoplasia; surgical management; colposcopy; lymph node management; molecular classification; sentinel lymph node procedure; HPV infection and prevention

Applications of High-Throughput Technologies in Cancer

edited by Timothy P. Spicer and

Rolf Renne

submission deadline 31 Oct 2026 | Viewed by 217 | Submission Open

Keywords: solid tumors; high throughput screening (HTS); artificial intelligence; drug discovery; antibody–drug conjugates (ADCs); CAR T cells; bispecific T cell engagers (BiTEs)

(This special issue belongs to the Section Methods and Technologies Development)

Beyond Breast Cancer—Rehabilitation for Survivorship

edited by

Elisabeth Kenne Sarenmalm

and

Jenny Nyqvist-Streng

submission deadline 31 Oct 2026 | Viewed by 204 | Submission Open

Keywords: breast cancer; rehabilitation; person-centered: clinical follow-up; physiotherapy; psycho-social support; existential support; patient education and self-management

Molecular Biology for Germ Cell Tumors

edited by

Shi-Ming Tu

submission deadline 31 Oct 2026 | Viewed by 204 | Submission Open

Keywords: germ cell tumors; intratumoral heterogeneity; cancer stem cells; somatic transformation; extragonadal germ cells; subsequent malignant neoplasms

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in MRI Applications for Neuro-Oncology

edited by

Siamak P. Nejad-Davarani

submission deadline 31 Oct 2026 | Viewed by 202 | Submission Open

Keywords: brain tumors; magnetic resonance imaging; MRI field strength; quantitative MRI; radiomics; imaging biomarkers

Biliary Tract Cancer: Challenges and Strategies in Centralizing Care for Rare Tumors

edited by Angela Lamarca

submission deadline 31 Oct 2026 | Viewed by 193 | Submission Open

Keywords: biliary tract cancer; centralization of care; recommendations

Progress in Skin Cancer: Diagnostics, Therapy, and Outcomes

edited by Marco Ardigo and Francesco Piscazzi

submission deadline 31 Oct 2026 | Viewed by 187 | Submission Open

Keywords: skin cancer; dermoscopy; reflectance confocal microscopy (RCM); line-field confocal optical coherence tomography (LC-OCT); non-invasive diagnostics; systemic therapy; locally advanced skin cancer; minimally invasive treatments; tumor prediction; clinical outcomes

Hepatocellular Carcinoma—from Molecular Insight to Surgical Strategy

edited by

Marcos Perini

submission deadline 31 Oct 2026 | Viewed by 173 | Submission Open

Keywords: hepatocellular carcinoma (HCC); clinical diagnosis; molecular biology; biomarkers; surgical strategy; liver transplantation; prognosis

Displaying special issue 251-300 on page 6 of 21.

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