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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Integrating Palliative Care in Oncology

edited by

Albert Tuca-Rodríguez

submission deadline 31 Dec 2025 | 13 articles | Viewed by 36350 | Submission Open

Keywords: early palliative care; advanced cancer; complexity of care needs; integration of palliative care in oncology; cancer pain; symptom control; end-of-life; advance care planning

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Skin Cancer: Diagnosis, Treatment and Prognosis

edited by Iris Zalaudek and

Roberta Giuffrida

submission deadline 31 Dec 2025 | 14 articles | Viewed by 35880 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Disparities in Cancer Prevention, Screening, Diagnosis and Management

edited by

Eliza W. Beal

submission deadline 31 Dec 2025 | 17 articles | Viewed by 35721 | Submission Open

Keywords: social determinants of health (SDOH); financial toxicity; racial disparities; ethnic disparities; LGBTQIA+ disparities; cultural competency; cancer; health status disparities; healthcare disparities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cervical Cancer: Screening and Treatment in 2024-2025

edited by

Fabrice Lécuru

and

Benedetta Guani

submission deadline 31 Dec 2025 | 8 articles | Viewed by 35633 | Submission Open

Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Perspectives in the Management of Breast Cancer

edited by

Sonia Santander Ballestín

and

María José Luesma

submission deadline 31 Dec 2025 | 12 articles | Viewed by 28495 | Submission Open

Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact

(This special issue belongs to the Section Cancer Therapy)

Advanced Diagnostics and Optical Imaging Technologies in Cancer Research

edited by Vlad Mihai Voiculescu

submission deadline 31 Dec 2025 | 12 articles | Viewed by 26965 | Submission Open

Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies

(This special issue belongs to the Section Methods and Technologies Development)

PTEN: Regulation, Signalling and Targeting in Cancer

edited by

Mark G.H. Scott

Larissa Kotelevets

and

Éric Chastre

submission deadline 31 Dec 2025 | 7 articles | Viewed by 25983 | Submission Open

Keywords: PTEN; tumour suppressor; phosphatase; AKT signalling; genome integrity; apoptosis; proliferation; cancer; biomarker; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Oral Potentially Malignant Disorders and Oral Cavity Cancer

edited by

I-Ta Lee

submission deadline 31 Dec 2025 | 8 articles | Viewed by 24444 | Submission Open

Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine

(This special issue belongs to the Section Cancer Therapy)

Oncology: State-of-the-Art Research and Initiatives in Japan

edited by

Satoshi Ikeda

and

Tateaki Naito

submission deadline 31 Dec 2025 | 8 articles | Viewed by 22685 | Submission Open

Keywords: Japan; cancer; oncology; research; clinical trial; survivorship; patient support

Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2024–2025

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 31 Dec 2025 | 4 articles | Viewed by 21884 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Medical Imaging and Artificial Intelligence in Cancer

edited by Debiao Li and

Stephen J. Pandol

submission deadline 31 Dec 2025 | 11 articles | Viewed by 21428 | Submission Open

Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Biology, Diagnosis and Management of Cervical Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

, Thomas Vrekoussis and

George Valasoulis

submission deadline 31 Dec 2025 | 6 articles | Viewed by 16265 | Submission Open

Keywords: cervical cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Updates in Neuroendocrine Neoplasms

edited by Jonathan Strosberg

submission deadline 31 Dec 2025 | 9 articles | Viewed by 15297 | Submission Open

Keywords: neuroendocrine tumors; neuroendocrine neoplasms; neuroendocrine carcinomas; therapy; germline mutations; somatic mutations

(This special issue belongs to the Section Cancer Therapy)

Advances in Chronic Lymphocytic Leukaemia (CLL) Research

edited by

H. Denis Alexander

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14648 | Submission Open

Keywords: chronic lymphocytic leukaemia; CLL; aetiology; oncogenic transformation; survival; cure

(This special issue belongs to the Section Cancer Therapy)

Long-Term Cancer Survivors: Rehabilitation and Quality of Life

edited by

Juan Rodríguez-Mansilla

Blanca Gonzalez-Sanchez

and

María Jiménez-Palomares

submission deadline 31 Dec 2025 | 7 articles | Viewed by 13775 | Submission Open

Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Advance of Biomarker-Driven Targeted Therapies in Cancer

edited by

Tianshun Zhang

, Qiushi Wang and Ann Bode

submission deadline 31 Dec 2025 | 5 articles | Viewed by 13242 | Submission Open

Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section "Tumor Microenvironment"

edited by

Sanjay Gupta

submission deadline 31 Dec 2025 | 6 articles | Viewed by 13145 | Submission Open

Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response

(This special issue belongs to the Section Tumor Microenvironment)

State-of-the-Art Treatment on Chemotherapy and Immunotherapy for Urological Cancer

edited by

Kouji Izumi

and Hiroshi Yaegashi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 12722 | Submission Open

Keywords: chemotherapy; immunotherapy; antibody– drug conjugate; radioligand therapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; urachal cancer; penile cancer; adrenal cancer; sarcoma; clinical trial; basic research

(This special issue belongs to the Section Tumor Microenvironment)

Robotic Surgery in Colorectal Cancer

edited by James Chi Yong Ngu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 12639 | Submission Open

Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy

(This special issue belongs to the Section Clinical Research of Cancer)

Advancements in Preclinical Models for Solid Cancers

edited by

Ewa Krawczyk

and Paula Dobosz

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12129 | Submission Open

Keywords: solid cancers; preclinical cancer models; in vitro cancer models; in vivo cancer models; translational cancer research; strengths and limitations of preclinical cancer models

(This special issue belongs to the Section Clinical Research of Cancer)

Surgery for Colorectal Cancer

edited by

Antonio V. Sterpetti

and

Raimondo Gabriele

submission deadline 31 Dec 2025 | 7 articles | Viewed by 12055 | Submission Open

Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer

(This special issue belongs to the Section Cancer Therapy)

The Applications of Artificial Intelligence in Gastroenterology

edited by

Marcello F. Maida

Ciro Celsa

and Louis H. S. Lau

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11786 | Submission Open

Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases

(This special issue belongs to the Section Cancer Therapy)

Physiotherapy in Advanced Cancer and Palliative Care

edited by Nele Adriaenssens

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11689 | Submission Open

Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Spine Oncology: Research and Clinical Studies

edited by Oluwaseun O. Akinduro

submission deadline 31 Dec 2025 | 8 articles | Viewed by 11632 | Submission Open

Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy

(This special issue belongs to the Section Clinical Research of Cancer)

Lymph Node Dissection for Gynecologic Cancers

edited by

Fabio Landoni

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11326 | Submission Open

(This special issue belongs to the Section Methods and Technologies Development)

Medical Complications and Supportive Care in Patients with Cancer (2nd Edition)

edited by

Javier Marco-Hernández

submission deadline 31 Dec 2025 | 10 articles | Viewed by 10492 | Submission Open

Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Unravelling Cancer Mechanism and Developing Novel Therapeutics: An Urgent Need to Treat Cancer (2nd Edition)

edited by

Santosh Kumar Singh

and

Rajesh Singh

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9995 | Submission Open

Keywords: cancer; anticancer therapy; combination therapy; natural compound; nanotherapy; exosome therapy; targeted therapy; immunotherapy; chemokines; cytokines; antibodies; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition

edited by

Andrew Stephens

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9795 | Submission Open

Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion

(This special issue belongs to the Section Cancer Biomarkers)

Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets

edited by

Annapina Russo

Giulia Russo

and

Annalisa Pecoraro

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9752 | Submission Open

Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction

(This special issue belongs to the Section Cancer Biomarkers)

Technological Development for Advances in Cancer Research and Precision Oncology

edited by

Nelson Yee

Ilias Georgakopoulos-Soares

and Fenglong Ma

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9215 | Submission Open

Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics

(This special issue belongs to the Section Molecular Cancer Biology)

Radiomics in Cancer

edited by Isabelle M. Germano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9143 | Submission Open

Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care

(This special issue belongs to the Section Cancer Therapy)

The Development and Application of Imaging Biomarkers in Cancer

edited by

Abhishek Mahajan

submission deadline 31 Dec 2025 | 5 articles | Viewed by 8610 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy in Non-Small Cell Lung Cancers

edited by Marco Russano

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8410 | Submission Open

Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advancements in Head and Neck Cancer Surgery

edited by

Carlos M. Chiesa-Estomba

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7906 | Submission Open

Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging

(This special issue belongs to the Section Clinical Research of Cancer)

Ovarian Cancer Stem Cells and Tumor Microenvironment

edited by

Carrie House

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7873 | Submission Open

Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts

(This special issue belongs to the Section Tumor Microenvironment)

Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics

edited by

Athanasios G. Papavassiliou

and

Le Zhang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7639 | Submission Open

Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications

(This special issue belongs to the Section Cancer Therapy)

Advances in Radiation Therapy for Head and Neck Cancer

edited by

Vassilis Kouloulias

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7144 | Submission Open

Keywords: adaptive radiotherapy ; hyper- and hypo-fractionated radiotherapy ; artificial intelligence in radiotherapy for head and neck cancer ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques ; protons and heavy ions for radiotherapy ; re-irradiation ; nanoparticles plus radiotherapy ; hyperthermia plus radiotherapy ; radiotherapy plus immunotherapy ; the de-escalation of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Non-muscle Invasive Bladder Cancer

edited by Paul L. Crispen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7090 | Submission Open

Keywords: non-muscle invasive bladder cancer; adjuvant therapy; surveillance; BCG refractory; intravesical therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Precision Oncology for Rare Skin Cancers

edited by Gino K. In and Aparna Nallagangula

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7045 | Submission Open

Keywords: rare skin cancers; melanoma; cutaneous squamous cell carcinoma; basal cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma; adnexal/sweat gland carcinoma; dermatofibrosarcoma protuberans; extramammary Paget’ s disease; cutaneous sarcomas

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Pancreatic Ductal Adenocarcinoma Diagnosis and Treatment 2nd Edition

edited by

Andrzej Deptała

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6934 | Submission Open

Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; genetic changes; genomics; surgical resection; radiotherapy; radiochemotherapy; chemotherapy; targeted therapy; immunotherapy; resectable tumor; borderline resectable tumor; metastatic disease; nutritional treatment; quality of life

(This special issue belongs to the Section Cancer Therapy)

Advances in Surgical Treatment of Urinary Tumors

edited by Pierre I. Karakiewicz and

Simone Morra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6834 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology

(This special issue belongs to the Section Cancer Therapy)

Hereditary and Familial Colorectal Cancer

edited by Bryson W. Katona and Peter P. Stanich

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6551 | Submission Open

Keywords: hereditary colorectal cancer; familial colorectal cancer; genetic predisposition; polyposis; Lynch syndrome; familial adenomatous polyposis (FAP); MUTYH-associated polyposis (MAP); genetic testing

(This special issue belongs to the Section Cancer Pathophysiology)

Artificial Intelligence-Assisted Radiomics in Cancer

edited by

Seong K. Mun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6395 | Submission Open

Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Enhancing Cancer Treatments through Fluorescence-Guided Surgery

edited by Ibrahim Khot and Yazan Sulaiman Khaled

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6276 | Submission Open

Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Treatment of Hepatocellular Carcinoma

edited by

Wei-Chen Lee

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6229 | Submission Open

Keywords: surgical techniques; surgical indications; surgical outcomes; clinical trials; liver transplantation; adjuvant therapy; basic research

(This special issue belongs to the Section Clinical Research of Cancer)

Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Urological Tumours

edited by

Magdalena Görtz

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6211 | Submission Open

Keywords: urological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cost-Effectiveness Studies in Cancers

edited by

Ippazio Cosimo Antonazzo

Paolo Angelo Cortesi

and

Pietro Ferrara

submission deadline 31 Dec 2025 | 5 articles | Viewed by 6169 | Submission Open

Keywords: cancer therapies; cost-effectiveness; cost-utility; cost-consequence; treatment economic impact; health economic; economic sustainability; public health; decision analytical models.

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Radiosurgery for Brain Tumors

edited by Anna Petoukhova

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6151 | Submission Open

Keywords: radiosurgery with photons and protons; stereotactic radiosurgery (SRS); brain tumors; gliomas; meningioma; pituitary adenoma; magnetic resonance imaging (MRI); magnetic resonance linac (MRL)

(This special issue belongs to the Section Cancer Therapy)

AI-Based Applications in Cancers

edited by

Xia Jiang

submission deadline 31 Dec 2025 | 6 articles | Viewed by 5916 | Submission Open

Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer

(This special issue belongs to the Section Cancer Informatics and Big Data)

Natural Compounds in Cancers: 2nd Edition

edited by