Targeting Tumor Microenvironment as a Novel Promising Approach in Adrenal Tumors
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 8983
Special Issue Editors
Interests: adrenal tumors; molecular and cell biology of endocrine tumors and metabolic pathologies
Interests: adrenal tumors; molecular and cell biology of adrenocortical carcinoma; adipose microenvironment
Special Issue Information
Dear Colleagues,
The recently emerging concept of the tumor microenvironment (TME) is radically changing the way of studying and addressing solid tumors. The TME consists of the complex and dynamic system of cells, soluble factors, matrix factors, and vasculature that form the niche where the tumor grows. The strict reciprocal interaction established between tumor cells and their microenvironment controls tumor development and progression. The complex nature of the adrenal gland structure significantly impacts the different types of tumors that interest this endocrine organ, namely benign and malignant neoplasia of the steroidogenic cortex (adrenocortical adenoma ACA and carcinoma ACC, respectively) and of the catecholamine producing medulla (pheochromocytoma PGL). The variety of hormonal production of the gland in pathophysiological conditions further modulates TME in adrenal tumors, in particular contributing to the immune escape condition of the tumor. The unsatisfactory results of the disease control so far obtained by pharmacological approaches in particular in the adrenal malignancies may be caused by focusing on tumor cells only, neglecting the role of TME in controlling tumor progression and local immune response, as further confirmed by the questionable effects achieved with immunotherapy.
This Special Issue will focus on the aspects of the unique tumor microenvironment characterizing adrenal tumors. A better understanding of the tumor microenvironment characteristics and of the complex crosstalk with the tumor itself will open novel opportunities to develop more effective and personalized therapies for adrenal tumors targeting the disease in the complexity of tumor–TME interaction.
Preclinical and clinical research articles are welcome, as well as reviews and pilot studies focused on cell biology, genetics, molecular mechanisms, diagnostic tools, in vitro and animal models, management, clinics, and therapies addressing the involvement of tumor microenvironment in adrenal tumors, including adrenocortical adenoma, carcinoma, and pheochromocytoma.
Prof. Dr. Michaela Luconi
Dr. Giulia Cantini
Prof. Dr. Matthias Kroiss
Guest Editors
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Keywords
- adrenal tumors
- adrenocortical adenomas
- adrenocortical carcinomas
- pheochromocytomas
- glucocorticoids
- immunotherapy
- cancer-associated fibroblasts (CAF), adipose cells (CAA), macrophages (CAM)
- tumor-infiltrating lymphocytes (TIL)
- genetic/epigenetic landscape
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