The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 15 April 2025 | Viewed by 13870
Special Issue Editor
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) is a complex biological structure composed of tumor cells, endothelial cells, immune cells, fibroblasts, macrophages, and the extracellular matrix surrounding or infiltrating tumor tissues, as well as soluble substances such as cytokines and growth factors secreted by these cells. TME plays a significant role in the control of the angiogenic process, tumor growth, and metastasis. Additionally, the nature of the TME has a significant impact on the effectiveness of therapeutic interventions. Through the management of various TME components, ranging from inhibitors of angiogenic cytokines and their receptors to the regulation of cells' activities and the emerging immune checkpoint inhibitors, several processes that are useful as molecular-targeted therapeutics have been discovered. Given that the mechanisms of tumor evasion and resistance typically lower the efficiency of these novel treatment modalities, they are now a key area of research.
Dr. Roberto Tamma
Guest Editor
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Keywords
- tumor microenvironment
- tumor angiogenesis
- tumor targeted therapies
- inflammation
- immunotherapies
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