Updates on Liver Cancer Management
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 1 October 2025 | Viewed by 1202
Special Issue Editor
Interests: liver resection; laparoscopic liver resection; hepatocellular carcinoma; liver metastasis; chemotherapy (neoadjuvant, induction); liver venoocclusive disease; anus neoplasms; intensity modulated radiation therapy; chemoradiotherapy
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Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) remains a significant global health burden due to its high incidence and mortality. Over the past few decades, significant progress has been achieved in the management of HCC, with advanced surgeries, including minimally invasive and robot-assisted procedures, liver transplantation, and local ablation therapy potentially offering a cure. Trans-arterial treatment techniques and radiation therapies are being developed further, while the recent introduction of immunotherapy opened a new systemic treatment landscape. The introduction of several classification system for HCC (such as BCLC), clearly defining patient groups and assigning reasonable treatment options, has standardized treatment. Currently, a comprehensive and multidisciplinary approach is crucial for the effective management of this disease.
On the other hand, intrahepatic cholangiocarcinoma (ICC) is the second most frequent primary liver cancer after HCC, showing increasing incidence and mortality. It originates from intrahepatic bile ducts and has a silent presentation, with a highly aggressive nature. Upon diagnosis, less than 40% of ICC are suitable for curative surgical therapy, which is, so far, the only curative treatment. Although there have been attempts at early diagnoses and providing patient-personalized treatment by molecular characterization, these aims are not easily achieved because of the heterogeneity of this tumor. However, recent progress has been made in the molecular characterization, surgical treatment, and management of this disease.
In this SI on “Updates on Liver Cancer Management” (including metastatic cancers), a comprehensive overview of the evolving management landscape and challenges to its improvements will be provided.
Prof. Dr. Zenichi Morise
Guest Editor
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Keywords
- laparoscopic liver resection
- minimally invasive liver resection
- deteriorated liver function
- anatomical resection
- preoperative simulation
- intraoperative navigation
- liver metastasis
- hepatocellular carcinoma biliary tract cancers
- robot-assisted liver resection
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