Immunotherapy of Non-Small Cell Lung Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 2965
Special Issue Editor
Special Issue Information
Dear Colleagues,
Antibody Drug Conjugates (ADCs) are the newer classes of immunotherapy drugs which present a promising but challenging therapeutic approach for Non-small cell lung cancer (NSCLC). They have shown promise in treating patients who have developed resistance to other therapies. Several ADCs are in clinical trial, targeting various antigens including TROP2, HER2 etc. Despite the promise, ADCs face significant challenges in NSCLC treatment including toxicity like interstitial lung disease (ILD), limited efficacy, identifying suitable surface targets and resistance. There is insufficient knowledge about how ADC targets are expressed in the body. A more thorough analysis of this expression could lead to a better understanding of adverse events, such as ILD. This improved understanding may help reduce the occurrence of these adverse effects. Our study aims to analyze the ADC target expression in lung tissue to help us understand the relation between ADCs and interstitial lung disease.
We look forward to receiving your contributions.
Dr. Aakash P. Desai
Guest Editor
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Keywords
- antibody drug conjugates
- ADCs
- non-small cell lung cancer
- NSCLC
- interstitial lung disease
- ILD
- TROP2
- ERBB2
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