The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma
AbstractHead and neck squamous cell carcinoma (HNSCC) affects 650,000 people worldwide and has a dismal 50% 5-year survival rate. Recurrence and metastasis are believed the two most important factors causing this high mortality. Understanding the biological process and the underlying mechanisms of recurrence and metastasis is critical to develop novel and effective treatment, which is expected to improve patients’ survival of HNSCC. MicroRNAs are small, non-coding nucleotides that regulate gene expression at the transcriptional and post-transcriptional level. Oncogenic and tumor-suppressive microRNAs have shown to regulate nearly every step of recurrence and metastasis, ranging from migration and invasion, epithelial-mesenchymal transition (EMT), anoikis, to gain of cancer stem cell property. This review encompasses an overview of microRNAs involved in these processes. The recent advances of utilizing microRNA as biomarkers and targets for treatment, particularly on controlling recurrence and metastasis are also reviewed. View Full-Text
Share & Cite This Article
Yang, C.X.; Sedhom, W.; Song, J.; Lu, S.-L. The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma. Cancers 2019, 11, 395.
Yang CX, Sedhom W, Song J, Lu S-L. The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma. Cancers. 2019; 11(3):395.Chicago/Turabian Style
Yang, Chris X.; Sedhom, Wafik; Song, John; Lu, Shi-Long. 2019. "The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma." Cancers 11, no. 3: 395.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.