Alternative and Aberrant Splicing in Cancer: How Can We Fix It?

Dear Colleagues,

Recent advances coming from new findings in functional analyses and high-throughput sequencing of cancer-related alternative and aberrant splicing events have given us clues to apply splice-modifying compounds and RNA-based therapeutics for various cancers.

RNA-based therapeutics include: RNA interference; antisense oligonucleotides; RNA aptamer; and ribozymes that have the advantages of high specificity, high potency, and low toxicity. However, there are still many challenges to be made: improvement of drug delivery, how to avoid off-target events, etc.

The main focus of this Special Issue is to extend the knowledge about therapeutics that target cancer-related alternative and aberrant splicing events. Studies describing mechanisms of cancer-related alternative and aberrant splicing, articles of cancer-related microRNA or circRNA etc., that may be a promising target for therapy are also welcome.

Prof. Dr. Kenji Ohe
Guest Editor

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