Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential

Dear Colleagues,

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that play pivotal roles in extracellular matrix (ECM) remodeling and degradation. They are involved in a wide range of physiological processes, including tissue repair, embryogenesis, and angiogenesis. However, dysregulation of MMP activity has been implicated in various pathological conditions, such as cancer, cardiovascular diseases, and inflammatory disorders. The multifaceted roles of MMPs in health and disease have made them a focal point of biomedical research.

This Special Issue aims to explore the latest advancements in MMP research, encompassing their molecular mechanisms, regulatory pathways, and functional implications. We invite original research articles, reviews, and perspectives that provide insights into the structural biology of MMPs, their role in tissue homeostasis and disease progression, and the development of MMP inhibitors as therapeutic agents. Through this compilation, we seek to enhance our understanding of MMPs and foster the development of novel therapeutic strategies targeting these versatile enzymes. 

Dr. Alireza Shoari
Dr. Joshua W. Ogony
Dr. Gokara Mahesh
Guest Editors

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