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9.4
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Biomolecules
Special Issues
Cellular Mechanics and Autophagy
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Cellular Mechanics and Autophagy

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3303

Special Issue Editor

Dr. Maria Vivo

E-Mail Website
Guest Editor
Department of Chemistry and Biology, University of Salerno, 84084 Fisciano, Italy
Interests: autophagy; cellular mechanics; cell biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Autophagy plays a central role in the recycling of cytosolic components, thus maintaining the balance among protein synthesis and degradation and lipid and organelle turn-over. Chemical and mechanical stresses stemming from the cellular microenvironment induce an autophagic cellular response. In particular, the cytoskeleton activates an intrinsic mechanical reaction through mechanosensitive protein complexes, which interface the cells with their mechano-environment. This crosstalk is particularly relevant as malignant transformation is accompanied by a progressive loss in tissue homeostasis and perturbations of tissue architecture. In this Special Issue, we aim to collect experimental evidence and discuss and stimulate novel questions about the role of physical forces in autophagy regulation and their potential implications in physiological and pathological conditions.

Dr. Maria Vivo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytoskeleton
  • mechano-sensing
  • nuclear structure
  • autophagosome
  • mechano-transduction
  • cellular mechanics
  • focal adhesions
  • extracellular matrix
  • cell architecture

Published Papers (1 paper)

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Review

19 pages, 2597 KiB  
Review
Alterations of Cytoskeleton Networks in Cell Fate Determination and Cancer Development
by Evan Ja-Yang Wang, I-Hsuan Chen, Brian Yu-Ting Kuo, Chia-Cheng Yu, Ming-Tsung Lai, Jen-Tai Lin, Leo Yen-Ting Lin, Chih-Mei Chen, Tritium Hwang and Jim Jinn-Chyuan Sheu
Biomolecules 2022, 12(12), 1862; https://doi.org/10.3390/biom12121862 - 13 Dec 2022
Cited by 3 | Viewed by 2935
Abstract
Cytoskeleton proteins have been long recognized as structural proteins that provide the necessary mechanical architecture for cell development and tissue homeostasis. With the completion of the cancer genome project, scientists were surprised to learn that huge numbers of mutated genes are annotated as [...] Read more.
Cytoskeleton proteins have been long recognized as structural proteins that provide the necessary mechanical architecture for cell development and tissue homeostasis. With the completion of the cancer genome project, scientists were surprised to learn that huge numbers of mutated genes are annotated as cytoskeletal or associated proteins. Although most of these mutations are considered as passenger mutations during cancer development and evolution, some genes show high mutation rates that can even determine clinical outcomes. In addition, (phospho)proteomics study confirms that many cytoskeleton-associated proteins, e.g., β-catenin, PIK3CA, and MB21D2, are important signaling mediators, further suggesting their biofunctional roles in cancer development. With emerging evidence to indicate the involvement of mechanotransduction in stemness formation and cell differentiation, mutations in these key cytoskeleton components may change the physical/mechanical properties of the cells and determine the cell fate during cancer development. In particular, tumor microenvironment remodeling triggered by such alterations has been known to play important roles in autophagy, metabolism, cancer dormancy, and immune evasion. In this review paper, we will highlight the current understanding of how aberrant cytoskeleton networks affect cancer behaviors and cellular functions through mechanotransduction. Full article
(This article belongs to the Special Issue Cellular Mechanics and Autophagy)
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