Cellular Mechanics and Autophagy
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 4724
Special Issue Editor
Interests: autophagy; cellular mechanics; cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autophagy plays a central role in the recycling of cytosolic components, thus maintaining the balance among protein synthesis and degradation and lipid and organelle turn-over. Chemical and mechanical stresses stemming from the cellular microenvironment induce an autophagic cellular response. In particular, the cytoskeleton activates an intrinsic mechanical reaction through mechanosensitive protein complexes, which interface the cells with their mechano-environment. This crosstalk is particularly relevant as malignant transformation is accompanied by a progressive loss in tissue homeostasis and perturbations of tissue architecture. In this Special Issue, we aim to collect experimental evidence and discuss and stimulate novel questions about the role of physical forces in autophagy regulation and their potential implications in physiological and pathological conditions.
Dr. Maria Vivo
Guest Editor
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Keywords
- cytoskeleton
- mechano-sensing
- nuclear structure
- autophagosome
- mechano-transduction
- cellular mechanics
- focal adhesions
- extracellular matrix
- cell architecture
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