Metabolic and Neurotrophic Pathways Driving the Brain-Heart-Axis

Dear colleagues,

Recent studies have underlined the role of metabolic and neurotrophic factors in whole body control, with a special focus on the “brain–heart axis”. Indeed, metabolic alterations are known to affect the brain function as well as the vascular system. In agreement, drugs used to cure hypertension, such as Verapamil, are also beneficial in neurological diseases. On the other hand, mutations in BDNF neurotrophin affect the brain function as well as the vascular system, with a special effect on the heart. It is becoming evident that metabolic alterations alter the expression/activity of neurotrophic factors, affecting the brain function and leading to heart dysfunction.

In this Special Issue, we aim to underline the effect of metabolic alterations that impact the activity of neurotrophic factors, leading to impaired brain activity, which in turn has an impact on heart function. Additionally, we invite articles showing that impaired neurotrophic activity impacts the brain, which consequently leads to impaired heart activity.

We look for innovative research capable to dissect the role of metabolism in altering the expression/activity of neurotrophic factors, showing the relevance of the “brain–heart axis”. Articles showing the role of mutations in molecules involved in the metabolic homeostasis or in neurotrophic factors are welcomed if they underline the relevance of the “brain–heart axis”.

Dr. Lorena Perrone
Prof. Dr. Carola Yvette Förster
Prof. Dr. Michiaki Nagai
Guest Editors

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