Molecular Mechanisms and Therapeutic Targeting of Autophagy in Cardiovascular Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 201
Special Issue Editor
Special Issue Information
Dear Colleagues,
Autophagy is a critical cellular process that helps to maintain cellular homeostasis by breaking down and recycling unnecessary or damaged components. Disruptions in autophagy have been linked to the development and progression of cardiovascular diseases. Researchers have identified various molecular mechanisms that play a role in autophagy and its relationship with cardiovascular diseases, including specific genes and proteins and the mTOR signaling pathway. Therapeutic targeting of autophagy has emerged as a promising approach to treat cardiovascular diseases. Small-molecule inhibitors, activators, and gene therapy approaches have been studied as potential therapeutic strategies. While small-molecule inhibitors have shown success in preclinical studies, further research is necessary to evaluate their safety and efficacy in humans. Gene therapy approaches, such as the delivery of autophagy-related genes to target tissues via adeno-associated virus (AAV) vectors, have also shown potential. Overall, targeting autophagy is a promising approach for treating cardiovascular diseases, and more research is needed to determine the most effective approaches and evaluate their safety and efficacy in human patients.
Dr. Yasuhiro Maejima
Guest Editor
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Keywords
- autophagy
- cardiovascular diseases
- molecular mechanisms
- therapeutic targeting
- mTOR signaling pathway
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