Special Issue "TGF-Beta Signaling in Physiology and Pathology"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 15 February 2020.

Special Issue Editors

Prof. Marie-José Goumans
E-Mail Website
Guest Editor
Leiden University Medical Center - LUMC, Department of Chemical Biology, Leiden, Netherlands
Dr. Gonzalo Sánchez-Duffhues
E-Mail Website
Guest Editor
Leiden University Medical Center - LUMC, Department of Molecular Cell Biology and Cancer Genomics Centre Netherlands, Leiden, Netherlands

Special Issue Information

Dear Colleagues,

The transforming growth factor b (TGF-β) family of cytokines comprises the TGF-β ligands (TGF-β1, TGF-β2, and TGF-β3) and the closely related bone morphogenetic proteins (BMPs), activins, and growth and differentiation factors (GDFs). These soluble factors exhibit tissue-specific effects through their interaction with cell membrane receptor complexes, which upon activation, activate cellular responses such as proliferation, differentiation, apoptosis, migration, adhesion, cytoskeletal organization, and extracellular matrix (ECM) production. Due to its key role in cell homeostasis, the signal transduction initiated by members of the TGF-β family is tightly controlled at multiple levels, for example, by means of extracellular antagonists, co-receptor molecules, and intracellular regulators.

TGF-β signaling plays multiple functions in development and adulthood, and genetic or environmental factors disturbing TGF-β signaling often result in a variety of pathologies, including cancer, cardiovascular disease, fibrosis, and skeletal disorders. Therefore, the elucidation of the mechanisms responsible for aberrant TGF-β signaling will contribute to the development of novel therapeutic approaches for multiple human diseases. This Special Issue aims to collect and summarize recent findings and developments in different areas of the field of TGF-β-driven (patho)physiology.

Prof. Marie-José Goumans
Dr. Gonzalo Sánchez-Duffhues
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Signal transduction
  • Cardiovascular
  • Skeletal
  • Fibrosis
  • Cancer
  • Development

Published Papers (2 papers)

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Review

Open AccessReview
Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
Biomolecules 2019, 9(10), 534; https://doi.org/10.3390/biom9100534 - 26 Sep 2019
Abstract
The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily, which play a key role in embryogenesis, organogenesis and regulation of [...] Read more.
The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily, which play a key role in embryogenesis, organogenesis and regulation of whole-body homeostasis. BMPs interact with membrane receptors that transduce information to the nucleus through SMAD-dependent and independent pathways, including PI3K-AKT and MAPKs. Reactive oxygen species (ROS) are intracellular molecules derived from the partial reduction of oxygen. ROS are highly reactive and govern cellular processes by their capacity to regulate signaling pathways (e.g., NF-κB, MAPKs, KEAP1-NRF2 and PI3K-AKT). Emerging evidence indicates that BMPs and ROS interplay in a number of ways. BMPs stimulate ROS production by inducing NOX expression, while ROS regulate the expression of several BMPs. Moreover, BMPs and ROS influence common signaling pathways, including PI3K/AKT and MAPK. Additionally, dysregulation of BMPs and ROS occurs in several pathologies, including vascular and musculoskeletal diseases, obesity, diabetes and kidney injury. Here, we review the current knowledge on the integration between BMP and ROS signals and its potential applications in the development of new therapeutic strategies. Full article
(This article belongs to the Special Issue TGF-Beta Signaling in Physiology and Pathology)
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Open AccessReview
The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis
Biomolecules 2019, 9(9), 476; https://doi.org/10.3390/biom9090476 - 11 Sep 2019
Abstract
The transforming growth factor-β (TGF-β) signaling pathway plays multiple regulatory roles in the tumorigenesis and development of cancer. TGF-β can inhibit the growth and proliferation of epithelial cells and induce apoptosis, thereby playing a role in inhibiting breast cancer. Therefore, the loss of [...] Read more.
The transforming growth factor-β (TGF-β) signaling pathway plays multiple regulatory roles in the tumorigenesis and development of cancer. TGF-β can inhibit the growth and proliferation of epithelial cells and induce apoptosis, thereby playing a role in inhibiting breast cancer. Therefore, the loss of response in epithelial cells that leads to the inhibition of cell proliferation due to TGF-β is a landmark event in tumorigenesis. As tumors progress, TGF-β can promote tumor cell invasion, metastasis, and drug resistance. At present, the above-mentioned role of TGF-β is related to the interaction of multiple signaling pathways in the cell, which can attenuate or abolish the inhibition of proliferation and apoptosis-promoting effects of TGF-β and enhance its promotion of tumor progression. This article focuses on the molecular mechanisms through which TGF-β interacts with multiple intracellular signaling pathways in tumor progression and the effects of these interactions on tumorigenesis. Full article
(This article belongs to the Special Issue TGF-Beta Signaling in Physiology and Pathology)
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