Advances in Oxygen Therapy with a Special Focus on Immunomodulation and Infection
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 4103
Special Issue Editor
2. Department of Anaesthesiology, Head-and-Orthopedic Centre, Copenhagen University Hospital—Rigshospitalet, Copenhagen, Denmark
Interests: the use of adjuvant HBOT in soft tissue and bony radiation injuries, ischemic wounds, diabetic foot ulcers, severe necrotizing soft tissue infections, and infections involving biofilm formation; decompression sickness and altitude decompression sickness; effects of oxygen on neurorehabilitation; effects of normobaric hypoxia and hyperoxia
Special Issue Information
Dear Colleagues,
Since the discovery and the subsequent mapping of the cell’s universal oxygen sensing mechanisms, now almost three decades ago, an increasingly large body of scientific evidence has emerged on the effects of oxygen fluctuation levels (i.e., DPO2 changes during both hypoxia and hyperoxia and hypo-, normo-, and hyperbaric pressure) under different pathophysiological conditions. It thus follows that oxygen availability and rapid changes or fluctuations thereof are an important signal transmitter including changes in hypoxia-induced factors (HIFs) and target genes. The key word is intermittent oxygen changes in contrast to long-term ones, involving several hours of continued normobaric oxygen breathing, where unwanted side effects may become more evident. Intermittent hyperbaric hyperoxia has been shown to stimulate wound healing, correct tissue ischemia and hypoxia, and, through controlled bursts of oxidative stress, induce regulation of bacterial metabolism and enhance certain antibiotics in the attempt to gain infection control. However, effects may be dependent on the sequence of events and timing of oxygen dosage. More research is clearly in demand, both with respect to pre-clinical, pathophysiological studies providing mechanistic insight into the many stimulating effects of cellular oxygen fluctuations and also with respect to human data and clinical trials investigating its impact on human disease outcome. In this Special Issue of Biomolecules, the focus will be on the effects of intermittent and fluctuating oxygen levels. The areas of interest may include but are not exclusively limited to:
- Hyperoxic (normo- and hyperbaric) fluctuations as a potential regulator as cellular oxygen sensing including hypoxia-induced factor (HIF) transcription;
- Hyperoxia fluctuations as an immune modulating stimulus in tissue infections;
- Hyperoxia as a regulator of bacterial metabolism and antibiotic susceptibility to bacterial killing mechanisms during biofilm formation in tissue infections.
In this context, we welcome original research, experimental in vitro or in vivo pathophysiological pre-clinical studies, as well as clinical reports—either retrospective, prospective or randomized trials—as well as systematic or narrative reviews to enhance scientific knowledge and distribution of new innovative ideas within the field of oxygen research.
Prof. Dr. Ole Hyldegaard
Guest Editor
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Keywords
- oxygen
- hyperoxia
- hyperbaric
- normobaric
- biofilm
- immune modulation
- sepsis
- septic shock
- infection
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