Role of Bioactive Compounds in the Regulation of Mitochondria and Oxidative Stress and Their Therapeutic Potential as Anti-cancer Agents

Dear Colleagues,

For the past two decades, bioactive compounds from plants, marine organisms, microorganisms, and endogenous factors have gained much attention in cancer treatment due to their significant efficacy and fewer adverse effects. In this context, recent research focused on the possibility of preventing or controlling cancer using bioactive compounds. Cancer is a leading cause of death in the world, accounting for about 10 million deaths in 2020. Chronic oxidative stress and inflammation have been implicated in the pathogenesis of several cancers. Cancer cells are known to manifest oxidative stress via abnormal energy metabolism including aerobic glycolysis (Warburg effect) or oxidative phosphorylation (OXPHOS) or both. Cancer metabolism-associated oxidative stress can account for cancer cells' survival and cell death; thus, the factors that regulate the homeostasis and/or dysregulation of oxidative signaling will be important biomarkers and therapeutic targets in cancer therapy. Therefore, bioactive compounds from natural herbs may alter the oxidative stress and the OXPHOS levels to interfere with the cancer formation, progression, or reoccurrence.

Dr. Arulkumar Nagappan
Prof. Dr. Yuseok Moon
Dr. Ki Hyung Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.