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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unraveling the Epigenetic Blueprint: Exploring DNA Methylation and Its Integration with Omics in Health and Disease

edited by Priyadarshini Kachroo and Rinku Sharma

submission deadline 31 May 2026 | Viewed by 408 | Submission Open

Keywords: multiomics; networks; epigenomics; machine learning; causation; early-life exposures; aging; translational therapeutics; metabolomics; epigenomics; exposomics; proteomics; microbiome

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Mechanism and Modulation in Radiotoxicity

edited by

Stephanie Puukila

, Siddhita Mhatre and Janani Iyer

submission deadline 31 May 2026 | Viewed by 305 | Submission Open

Keywords: radiation; cellular damage; dose; tissue sensitivity; countermeasures

(This special issue belongs to the Section Cell Biology and Pathology)

Exploring Conventional and Alternative Animal Models in Biomedical Research (Biomedicines)

edited by

Elisa Panzarini

and

Stefania Mariano

submission deadline 31 May 2026 | Viewed by 256 | Submission Open

Keywords: disease modelling; drug discovery and delivery; toxicology; personalized medicine; bioengineering; computational biology; ethical considerations; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

Poly-Pharmacological Effects and Mechanisms of Phytochemicals

edited by

Jiawen Shou

submission deadline 31 May 2026 | Viewed by 247 | Submission Open

Keywords: phytochemicals; natural products; poly-pharmacology; novel application; research updates on phytochemicals

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Regulation of Bone Homeostasis: Crosstalk Between Osteoblasts and Osteoclasts

edited by

Xiangguo Che

submission deadline 31 May 2026 | Viewed by 246 | Submission Open

Keywords: bone homeostasis; bone remodeling; osteoporosis; vascular calcification; osteoblast; osteoclast; signaling pathways; cellular communication; regulatory mechanisms

(This special issue belongs to the Section Cell Biology and Pathology)

Tumor Biomarkers in Gynecology—2nd Edition

edited by

Corrado Terranova

and

Francesco Plotti

submission deadline 31 May 2026 | Viewed by 238 | Submission Open

Keywords: gynecological cancers; precision medicine; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Stem Cell Therapy and Tissue Engineering

edited by

Nurettin Sahiner

submission deadline 31 May 2026 | Viewed by 234 | Submission Open

Keywords: stem cells; stem cell therapy; stem cell cancer therapy; hydrogels/cryogels; porous network biomaterials; tissue engineering

(This special issue belongs to the Section Cell Biology and Pathology)

Neurodevelopmental Disorders: From Mechanisms to Therapeutic Approaches

edited by Manuel López-Aranda

submission deadline 31 May 2026 | Viewed by 233 | Submission Open

Keywords: neurodevelopmental disorders; autism spectrum disorder (ASD); attention-deficit/hyperactivity disorder (ADHD); intellectual disability; schizophrenia; neuroimaging; molecular mechanisms; genetic and epigenetic factors; translational neuroscience; therapeutic interventions

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Emerging Trends in Cancer: Biomarkers, Therapeutic Strategies and Future Directions

edited by Nedime Serakinci

submission deadline 31 May 2026 | Viewed by 230 | Submission Open

Keywords: cancer biomarkers; stem cells; personalized medicine; emerging cancer therapies; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in Chronic Kidney Diseases

edited by

Mayra Trentin-Sonoda

submission deadline 31 May 2026 | Viewed by 208 | Submission Open

Keywords: chronic kidney disease; biomarkers; extracellular vesicles; SGLT2 inhibitors

(This special issue belongs to the Section Molecular and Translational Medicine)

Artificial Intelligence Applications in Cancer and Other Diseases—2nd Edition

edited by

Raji Sundararajan

submission deadline 31 May 2026 | Viewed by 206 | Submission Open

Keywords: artificial intelligence; machine learning; neural networks; deep learning; obesity; diabetes; cancer; other diseases; pathology; drug discovery

(This special issue belongs to the Section Biomedical Engineering and Materials)

Immune Checkpoint Regulation and Signaling Pathways in Cancer

edited by Sreeja C. Sekhar

submission deadline 31 May 2026 | Viewed by 182 | Submission Open

Keywords: tumor-immune evasion and interaction; immune check point inhibition; PD-1/PDL-1 pathway; T-cell exhaustion and tumor microenvironment; single-cell profiling; therapeutic resistance; tumor-infiltrating cells; checkpoint inhibitors and immune modulation

(This special issue belongs to the Section Immunology and Immunotherapy)

Mechanistic Insights into Protein Dynamics: Membrane Interactions, Phase Separation, and Disease-Linked Aggregation

edited by Ramesh Prasad

submission deadline 31 May 2026 | Viewed by 158 | Submission Open

Keywords: protein conformational dynamics; membrane-mediated interactions; liquid– liquid phase separation (LLPS); neurodegenerative protein aggregation; structural biology techniques

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in Circadian Rhythms

edited by

Ivana Škrlec

and Zrinka Biloglav

submission deadline 31 May 2026 | Viewed by 100 | Submission Open

Keywords: circadian rhythms; biological clocks; chronobiology; sleep– wake regulation; clock genes; chronotherapy; temporal physiology; circadian misalignment; molecular chronobiology; circadian biomarkers

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Regulatory T Cells and Immune Balance: From Tolerance to Therapy

edited by

Aline Yen Ling Wang

submission deadline 31 May 2026 | Viewed by 80 | Submission Open

Keywords: Treg cells; regulatory T cells; FoxP3 signaling; immune homeostasis; immune response

(This special issue belongs to the Section Cell Biology and Pathology)

Immunometabolism in Cancer and Autoimmunity: Mechanisms and Therapeutic Targeting

edited by

Xiancai Zhong

submission deadline 31 May 2026 | Viewed by 76 | Submission Open

Keywords: immunometabolism; cancer; autoimmunity; metabolic reprogramming; nutrient sensing; organelle dynamics; metabolic interventions

(This special issue belongs to the Section Immunology and Immunotherapy)

Advances in Pain Management: Exploring Molecular Mechanisms and Novel Therapies

edited by

Christopher Robinson

Samuel Ang

and Rodrigo Diez-Tafur

submission deadline 31 May 2026 | Viewed by 73 | Submission Open

Keywords: chronic pain; neuroinflammation; sensory signaling; epigenetics; neuroimmune interactions; regenerative medicine; stem cells

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovations in Kidney Disease: From Pathogenesis to Therapy

edited by

Yupei Li

submission deadline 31 May 2026 | Viewed by 71 | Submission Open

Keywords: kidney disease pathogenesis; therapeutic innovations; biomarkers; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Bioengineering, Biotechnology and Pharmacological Approaches in Cardiovascular Disease, Heart Failure, and Critical Care

edited by

Talal Almas

submission deadline 31 May 2026 | Viewed by 70 | Submission Open

Keywords: cardiogenic shock; heart failure; device therapeutics; mechanical circulatory support; cardiovascular prevention; hypertension; dyslipidemia

(This special issue belongs to the Section Biomedical Engineering and Materials)

Asthma and Allergy: New Therapeutic Frontiers and Patient Perspectives in a Changing World

edited by Maria Teresa Ventura and

Antonio Francesco Maria Giuliano

submission deadline 31 May 2026 | Viewed by 54 | Submission Open

Keywords: asthma; allergy; biologics; vaccines; digital health; precision medicine; severe asthma; gender medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovative Drug Target Discovery in Cancer: From Molecular Mechanisms to Therapeutic Targets

edited by Rakesh Nair

submission deadline 31 May 2026 | Viewed by 45 | Submission Open

Keywords: cancer therapy; drug target; drug resistance; oncology drug development; cancer metastasis mechanisms; signaling pathways; biomarker

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Mitochondrial Dysfunction in Health and Disease: Implications for Cellular Metabolism and Therapeutic Approaches

edited by Chellakkan S. Blesson

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: mitochondria; metabolic reprogramming; cellular metabolism; ROS; mitochondrial dynamics; mitochondrial dysfunction

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Cardiovascular Disease: Mechanisms and Treatments

edited by Shuai Guo and Aleksandar Jovanovic

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: cardiac and circulatory diseases; multisystem interactions and comorbidities; molecular mechanisms; cardiac imaging; novel therapies; regenerative medicine; health technologies

(This special issue belongs to the Section Molecular and Translational Medicine)

Current Challenges and Future Perspectives of Antimicrobial Therapy

edited by

Carmen Maximiliana Dobrea

and

Anca-Maria Arseniu

submission deadline 31 May 2026 | Viewed by 42 | Submission Open

Keywords: antibiotics; antifungals; antimicrobial resistance; antimicrobial stewardship; drug safety and efficacy; resistance mechanisms

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Progress in Wound Healing

edited by

Nsrein Ali

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: wound healing; tissue engineering; nanoparticle

(This special issue belongs to the Section Biomedical Engineering and Materials)

Molecular Mechanisms and Therapeutic Approaches for Oral Disorders: 2nd Edition

edited by Simona Santonocito and

Vincenzo Ronsivalle

submission deadline 31 May 2026 | Viewed by 40 | Submission Open

Keywords: oral diseases; drugs; local drug delivery; periodontitis; causal periodontal therapy; oral potential malignant disorders; oral cancer; oral medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Cardiovascular–Kidney–Metabolic Syndrome: Experimental Insights into Inflammation and Oxidative Stress Mechanisms

edited by

Vasileios Vazgiourakis

and Sihle Ephraim Mabhida

submission deadline 31 May 2026 | Viewed by 38 | Submission Open

Keywords: cardiovascular– kidney– metabolic syndrome; inflammation; oxidative stress; mitochondrial dysfunction; metabolic dysregulation; renal injury; cardiovascular remodeling; therapeutic targets; experimental pathophysiology; insulin resistance

(This special issue belongs to the Section Cell Biology and Pathology)

The Evolving Landscape of Systemic Vasculitides: From the Bench to Bedside

edited by Daniela Opriș-Belinski

submission deadline 31 May 2026 | Viewed by 36 | Submission Open

Keywords: systemic vasculitis; large vessel vasculitis; small vessel vasculitis; autoimmunity; inflammation; biomarkers; ANCA-associated vasculitis; translational research; imaging; precision medicine; immunopathogenesis; biologic therapies; real-world data; interdisciplinary care

(This special issue belongs to the Section Molecular and Translational Medicine)

mRNA Personalized Cancer Vaccines and Immune-Oncology

edited by Praveen Neeli

submission deadline 31 May 2026 | Viewed by 35 | Submission Open

Keywords: neoantigen prediction; mRNA vaccine; cancer immunotherapy; immuno-oncology

(This special issue belongs to the Section Immunology and Immunotherapy)

Lipid Metabolism and Lipidomics in Human Diseases

edited by

Ilenia Calcaterra

submission deadline 31 May 2026 | Viewed by 34 | Submission Open

Keywords: lipid metabolism; lipidomics; biomarkers; cardiovascular disease; metabolic syndrome; inflammation; PCSK9 inhibitors; personalized medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Bone, Tooth, and Periodontal Ligament Regeneration Biomaterial Advances

edited by

Ariadne C.C. Cruz

and Marianne Sordi

submission deadline 31 May 2026 | Viewed by 29 | Submission Open

Keywords: bone regeneration; tooth regeneration; periodontal ligament; biomaterials; organoids; scaffolds; bioactive ceramics; polymers; composites; tissue engineering; stem cells; growth factors; clinical translation

(This special issue belongs to the Section Biomedical Engineering and Materials)

Precision Anticoagulation: The Future of Thrombosis and Anticoagulation Therapy

edited by Jingyuan Tan

submission deadline 31 May 2026 | Viewed by 26 | Submission Open

Keywords: precision anticoagulation; venous thromboembolism; anticoagulation management; bleeding risk prediction; direct oral anticoagulants; risk stratification; clinical decision support; artificial intelligence; hospitalized patients; thromboprophylaxis

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Immunology and Immunotherapy

edited by Narges Baluch

submission deadline 31 May 2026 | Viewed by 20 | Submission Open

Keywords: immunology; immunotherapy; immune checkpoints; CAR/TCR cell therapy; mRNA vaccines

(This special issue belongs to the Section Immunology and Immunotherapy)

Dermatology: From Fundamental to Clinical Research

edited by Piotr K. Krajewski

submission deadline 31 May 2026 | Viewed by 15 | Submission Open

Keywords: dermatologic agents; skin diseases; translational research; signal transduction; immunity; biomarkers; precision medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Crosstalk Between Cardiovascular Health and Cellular Metabolism

edited by

Ivana Jukić

and

Ana Stupin

submission deadline 31 May 2026 | Viewed by 14 | Submission Open

Keywords: cellular metabolism; oxidative stress; antioxidants; cardiovascular health; inflammation; metabolic disorders

(This special issue belongs to the Section Cell Biology and Pathology)

Neurodegenerative Diseases: Recent Advances and Future Perspectives, 2nd Edition

edited by

Inés López-Cuenca

and

Rosa De Hoz

submission deadline 25 Jun 2026 | 2 articles | Viewed by 4635 | Submission Open

Keywords: neurodegeneration; neuroprotection; dementia; Parkinson’ s disease

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Dualistic Equilibrium in Neurotransmission and Beyond: Unraveling the Pathophysiology and Unlocking Novel Therapeutic Targets in Neuropsychiatric Disorders—2nd Edition

edited by

Masaru Tanaka

and

Simone Battaglia

submission deadline 30 Jun 2026 | 1 articles | Viewed by 7633 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; cognitive dysfunction; multiple sclerosis; stroke; migraine; chronic pain; depressive disorder; bipolar disorder; post-traumatic stress disorder; anxiety disorder; schizophrenia; somatic symptom disorder; autism spectrum disorder; hyperactive attention deficit disorder; learning disabilities; brain injuries; comorbidity; brain plasticity; transcranial magnetic stimulation (TMS); transcranial direct current stimulation (tDCS)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Renin-Angiotensin System in Cardiovascular Biology, 2nd Edition

edited by

Mária Szekeres

György L. Nádasy

and

László Dézsi

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5316 | Submission Open

Keywords: renin– angiotensin system (RAS); signaling mechanisms of angiotensin receptors; GPCR; AT1R; AT2R; ACE; ACE2; ACEI; angiotensin II; signal transduction; cardiovascular system; hypertension; atherosclerosis; heart failure; cardiovascular remodeling; osmoregulation; inflammation

(This special issue belongs to the Section Molecular and Translational Medicine)

Sphingolipid Metabolism and Signaling in Health and Diseases: 2nd Edition

edited by

Giulia Lunghi

Elena Chiricozzi

and

Maria Fazzari

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3744 | Submission Open

Keywords: sphingolipids; glycosphingolipids; gangliosides; sphingosine-1-phosphate; cell homeostasis; neurodegeneration; neurodevelopment; inflammation; diabetes; cystic fibrosis; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches (4th Edition)

edited by

Juan Gambini

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3290 | Submission Open

Keywords: oxidative stress; inflammation; molecular mechanisms; pharmacotherapy; longevity; aging

(This special issue belongs to the Section Immunology and Immunotherapy)

Prostate Cancer Targeted Therapy: Highlighting Advances in Precision Medicine and Rational Combination Approaches

edited by Alan P. Lombard

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3135 | Submission Open

Keywords: prostate cancer; precision medicine; targeted therapeutics; rational drug combinations; clinical biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Inherited Retinal Diseases: From Pathomolecular Mechanisms to Therapeutic Strategies, 2nd Edition

edited by

José Martín-Nieto

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1661 | Submission Open

Keywords: blindness; gene and protein function; pathogenesis; personalized diagnosis; precision therapy; retina; retinal degeneration

(This special issue belongs to the Section Molecular and Translational Medicine)

Diagnostic and Therapeutic Challenges of CAR-T Cell Therapy

edited by Vincenzo Maria Perriello

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1545 | Submission Open

Keywords: CAR-T therapy; immunotherapy; relapsed/refractory diffuse large B cell lymphoma (r/r DLBCL); relapsed/refractory mantle cell lymphoma (r/r MCL); B-acute lymphoblastic leukemia (r/r B-ALL); bridging therapy; cytokine release syndrome (CRS); immune effector cell associated neurotoxicity (ICANS); biomarkers; PET/CT assessment after CAR-T cell therapy

(This special issue belongs to the Section Gene and Cell Therapy)

Updates on Kawasaki Disease

edited by Eisuke Suganuma

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1425 | Submission Open

Keywords: coronary artery aneurysm; cluster; individualized treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Epilepsy: Pathomechanism, Diagnostics, and Novel Treatment Options

edited by

Monika Rudkowska

and

Karolina Wojtunik-Kulesza

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1118 | Submission Open

Keywords: epilepsy; pathophysiology; neurobiology; molecular pathways; experimental models of epilepsy; neuroinflammation; seizure prediction; biomarker discovery; electrophysiological studies; precision neurology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Type 2 Diabetes: Insulin Regulation and Therapeutic Strategies

edited by

Syed A. A. Rizvi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 896 | Submission Open

Keywords: type 2 diabetes; insulin regulation; glycemic control; insulin resistance; therapeutic strategies; personalized medicine; GLP-1 receptor agonists; SGLT2 inhibitors; novel insulin formulations; non-insulin therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

State-of-the-Art Immunology and Immunotherapy in Europe (2nd Edition)

edited by

Juan Gambini

submission deadline 30 Jun 2026 | Viewed by 648 | Submission Open

Keywords: immunology; immunotherapy; lymphocytes; macrophages; eosinophils; neutrophils; diseases

(This special issue belongs to the Section Immunology and Immunotherapy)

Feature Reviews in Cardiovascular Diseases, 2nd Edition

edited by

Serafino Fazio

and

Arturo Cesaro

submission deadline 30 Jun 2026 | Viewed by 607 | Submission Open

Keywords: cardiovascular diseases; heart failure; cardiac arrhythmias; metabolic syndrome; stroke; pulmonary hypertension; peripheral artery disease (PAD); acute coronary syndrome; myocarditis; pericarditis; valvulopathies

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on the Role of Biogenic Amines in Physiological and Pathological Conditions

edited by

Pellegrino Lippiello

Luisa Speranza

and

Maria Grazia Ferraro

submission deadline 30 Jun 2026 | Viewed by 466 | Submission Open

Keywords: biogenic amines; memory; synapse; depression; anxiety; schizophrenia; glioma and neurodegenerative diseases

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in 3D Bioprinting: From Materials to Functional Tissue Constructs

edited by

Tina Maver

submission deadline 30 Jun 2026 | Viewed by 165 | Submission Open

Keywords: 3D bioprinting; tissue engineering; biofabrication; regenerative medicine; bioprinted skin; organ-on-a-chip; biomaterials; vascularized constructs

(This special issue belongs to the Section Biomedical Engineering and Materials)

Displaying special issue 651-700 on page 14 of 15.

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