Regulation of Bone Homeostasis: Crosstalk Between Osteoblasts and Osteoclasts
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 8 January 2027 | Viewed by 1687
Editor
Interests: bone metabolism and homeostasis; osteoblast and osteoclast signaling; vascular calcification and bone-vascular interactions; molecular mechanisms of skeletal diseases; lipid metabolism and bone remodeling
Special Issue Information
Dear Colleagues,
Bone homeostasis is a tightly regulated process governed by the dynamic balance between bone-forming osteoblasts and bone-resorbing osteoclasts. Disruptions in this equilibrium contribute to skeletal disorders such as osteoporosis, osteoarthritis, and vascular calcification. Understanding the molecular and cellular mechanisms that regulate osteoblast–osteoclast interactions is crucial for developing novel therapeutic strategies to treat bone-related diseases. This Special Issue aims to explore the latest advances in bone biology, focusing on signaling pathways, cellular communication, extracellular vesicles, and regulatory mechanisms that maintain bone homeostasis. We welcome original research and review articles on topics, including but not limited to the following research areas: osteoblast–osteoclast crosstalk, the impact of inflammatory and metabolic factors on bone remodeling, and emerging therapeutic targets for bone disorders. Studies investigating the intersection between vascular and skeletal systems are also encouraged. By gathering insights from multidisciplinary approaches—including molecular biology, bioinformatics, genetics, and translational medicine—this Special Issue seeks to provide a comprehensive understanding of the regulatory networks controlling bone metabolism.
Dr. Xiangguo Che
Guest Editor
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Keywords
- bone homeostasis
- bone remodeling
- osteoporosis
- vascular calcification
- osteoblast
- osteoclast
- signaling pathways
- cellular communication
- regulatory mechanisms
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