Cardiovascular–Kidney–Metabolic Syndrome: Experimental Insights into Inflammation and Oxidative Stress Mechanisms
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 9
Special Issue Editors
Interests: molecular medicine; cardiovascular diseases; echocardiography; intensive care medicine; molecular genetics
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular kidney metabolic syndrome; inflammation and oxidative stress; experimental models (in vitro and in vivo); mechanistic pathophysiology
Special Issue Information
Dear Colleagues,
Cardiovascular–kidney–metabolic (CKM) syndrome is a recently recognized multisystem disorder characterized by a complex interplay between metabolic dysfunction, cardiovascular injury, and renal impairment. Mounting experimental evidence suggests that inflammation and oxidative stress are central drivers of this pathophysiological network, contributing to vascular dysfunction, cardiac remodeling, renal injury, and metabolic dysregulation. Despite the clinical relevance of CKM syndrome, mechanistic studies remain limited.
This Special Issue aims to highlight cutting-edge in vitro and in vivo experimental research that elucidates the biological mechanisms linking inflammation and oxidative stress to CKM syndrome. We welcome studies exploring novel animal models (e.g., diet-induced or surgical models), cellular and molecular pathways, mitochondrial dysfunction, biomarker discovery, and the crosstalk between metabolic, renal, and cardiovascular systems. Additionally, we encourage submissions investigating potential therapeutic targets and preclinical interventions aimed at mitigating inflammation and oxidative stress in CKM syndrome.
By integrating mechanistic research from experimental biology, this Special Issue seeks to advance our understanding of CKM pathophysiology and foster the development of innovative strategies for early prevention and treatment.
Dr. Vasileios Vazgiourakis
Dr. Sihle Ephraim Mabhida
Guest Editors
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Keywords
- cardiovascular–kidney–metabolic syndrome
- inflammation
- oxidative stress
- mitochondrial dysfunction
- metabolic dysregulation
- renal injury
- cardiovascular remodeling
- therapeutic targets
- experimental pathophysiology
- insulin resistance
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