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Biomedicines
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Dermatology: From Fundamental to Clinical Research
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Dermatology: From Fundamental to Clinical Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 4326

Editor

Dr. Piotr K. Krajewski

E-Mail Website
Guest Editor
Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 50-377 Wroclaw, Poland
Interests: skin diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dermatology is a rapidly advancing specialty that seamlessly integrates fundamental biological insights with clinical application. It provides valuable perspectives on inflammation, immune responses, genetic influences, and systemic diseases. Recent breakthroughs in molecular dermatology, immunopathology, and bioinformatics have significantly deepened our understanding of skin homeostasis and the mechanisms behind its disruption in conditions like psoriasis, atopic dermatitis, hidradenitis suppurativa, alopecia areata, and autoimmune blistering diseases. Translational research continues to reveal the intricate communication between the skin and other organs, highlighting the integumentary system’s role as both a reflection and a target of systemic pathology.

This Special Issue of Biomedicines—“Dermatology: From Fundamental to Clinical Research”—aims to highlight high-quality original research, comprehensive reviews, and innovative clinical studies that connect bench discoveries with bedside applications. Topics of interest include, but are not limited to, molecular and cellular mechanisms of skin disease, novel biomarkers, This Special Issue of Biomedicines, titled “Dermatology: From Fundamental to Clinical Research,” is dedicated to showcasing high-caliber original research, comprehensive reviews, and innovative clinical studies that bridge fundamental discoveries with clinical practice. The topics covered encompass molecular and cellular mechanisms underlying skin diseases, identification of novel biomarkers, therapeutic targets, regenerative dermatology, as well as advancements in dermatosurgery and trichology. By fostering collaboration between basic scientists and clinicians, this issue aims to enhance interdisciplinary dialogue and guide future developments toward personalized approaches in dermatologic care.

Ultimately, this collection will serve as a platform for disseminating the latest breakthroughs that shape modern dermatology and improve patient outcomes through precision medicine.

Dr. Piotr K. Krajewski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatologic agents
  • skin diseases
  • translational research
  • signal transduction
  • immunity
  • biomarkers
  • precision medicine

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Published Papers (2 papers)

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Review

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26 pages, 2240 KB  
Review
Cutaneous Dendritic Cells: Structure, Function and Immune Role
by Ioana Cristina Alexandru, Mariana Grigore and Olga Simionescu
Biomedicines 2026, 14(2), 460; https://doi.org/10.3390/biomedicines14020460 - 19 Feb 2026
Viewed by 2051
Abstract
Cutaneous antigen-presenting cells (APCs), particularly dendritic cells (DCs) and Langerhans cells (LCs), are a diverse population of cells that play a vital role in immune surveillance by initiating and shaping skin immune responses. They link innate and adaptive immunity by presenting antigens, migrating, [...] Read more.
Cutaneous antigen-presenting cells (APCs), particularly dendritic cells (DCs) and Langerhans cells (LCs), are a diverse population of cells that play a vital role in immune surveillance by initiating and shaping skin immune responses. They link innate and adaptive immunity by presenting antigens, migrating, and activating T lymphocytes, thereby acting as orchestrators of tissue immunity. This review provides an updated overview of the morphofunctional diversity of cutaneous APCs, ranging from epidermal LCs and DCs, to dermal conventional DCs (DC1/DC2), plasmacytoid DCs (pDCs), including newly defined subsets such as DC3, Axl+Siglec-6+ DCs (ASDCs) and LAMP3+ mature regulatory DCs (mRegDCs). Dynamic differences in APC composition and function between homeostatic and inflamed skin are discussed, with particular emphasis on inflammatory and autoimmune conditions such as psoriasis, lupus erythematosus and chronic atopic dermatitis, in which distinct DC subsets contribute to Th1 and Th17 immune circuits. This review is the first skin-related approach that extensively discusses the cutaneous role of APCs in the neuro-immune-cutaneous axis, as well as their interactions with the local microenvironment. Ongoing controversies regarding the classification and stability of certain DC populations are discussed. A better understanding of the diversity, migration mechanisms and microenvironmental interactions of cutaneous APCs could lead to the identification of new biomarkers and therapeutic targets for inflammatory, autoimmune, and oncological skin diseases. Full article
(This article belongs to the Special Issue Dermatology: From Fundamental to Clinical Research)
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21 pages, 11557 KB  
Systematic Review
Dupilumab in Elderly Patients with Atopic Dermatitis—A Systematic Review and Meta-Analysis
by Przemysław Hałubiec, Natalia Gołąbek, Anna Wojas-Pelc, Jacek Cezary Szepietowski and Andrzej Kazimierz Jaworek
Biomedicines 2026, 14(1), 204; https://doi.org/10.3390/biomedicines14010204 - 17 Jan 2026
Viewed by 1744
Abstract
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic eczematous lesions that significantly alter quality of life of patients. Dupilumab, a new biologic agent, has demonstrated efficacy and safety in the general adult population with AD. However, evidence on [...] Read more.
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic eczematous lesions that significantly alter quality of life of patients. Dupilumab, a new biologic agent, has demonstrated efficacy and safety in the general adult population with AD. However, evidence on its use in elderly patients is limited. Objectives: The objective of this work was to systematically assess the effectiveness and safety of dupilumab in patients aged ≥60 years with AD, based on published data. Methods: A systematic review and meta-analysis were conducted following the PICO(S) framework. Articles written in English and published before 31 December 2024 that investigated patients ≥ 60 years with AD treated with dupilumab were included. Meta-analysis of the observational studies was performed using a random-effects model with subgroup and meta-regression analyses. Results: Twenty-one articles met the inclusion criteria. After 16 weeks of treatment, dupilumab significantly reduced disease severity (EASI: 21.8; 95% CI: 18.3–25.2), intensity of pruritus (P-NRS: 5.8; 95% CI: 4.2–7.3), and quality of life impairment (DLQI: 11.3; 95% CI: 6.1–16.5); all p < 0.001. Meta-regression revealed previous treatment with cyclosporin A as a predictor of a poorer response to treatment. The generalized-prurigo phenotype was associated with worse control of pruritus. The most common adverse events were conjunctivitis, injection site reactions, and facial flushing. Conclusions: Dupilumab appears to be an effective and well-tolerated treatment for AD in elderly patients. More research is warranted to evaluate its long-term effectiveness and safety in this age group. Full article
(This article belongs to the Special Issue Dermatology: From Fundamental to Clinical Research)
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