Advances in Cardiovascular Disease: Mechanisms and Treatments

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 942

Special Issue Editors


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Guest Editor
Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Interests: cardiac electrophysiology; ion channel; cardiac and circulatory diseases

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Guest Editor
1. Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia CY-1700, Cyprus
2. Center for Neuroscience and Integrative Brain Research (CENIBRE), University of Nicosia Medical School, Nicosia CY-1700, Cyprus
Interests: cardioprotection; heart; cell signalling
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Special Issue Information

Dear Colleagues,

Cardiovascular disease remains the leading cause of death worldwide, imposing a significant burden on healthcare systems and societies. Despite considerable advancements in prevention, diagnosis, and therapy, many challenges remain in understanding the complex mechanisms that drive cardiovascular pathology.

We are pleased to invite you to contribute to this Special Issue, “Advances in Cardiovascular Disease: Mechanisms and Treatments”, which aims to bring together cutting-edge research and comprehensive reviews from experts in the field.

This Special Issue aims to provide an up-to-date overview of recent advances in the understanding of cardiovascular disease mechanisms and the development of novel diagnostic and treatment strategies. We welcome submissions encompassing basic, translational, and clinical research that explore the latest advances in the understanding of cardiovascular disease mechanisms, diagnostics, and treatment strategies.

Suggested topics include, but are not limited to, the following:

  • Cardiac and circulatory diseases;
  • Inflammation and oxidative stress in cardiovascular pathology;
  • Advances in cardiovascular imaging technologies and diagnostics;
  • Regenerative medicine and precision cardiology;
  • Gene therapy, RNA-based therapeutics, and epigenetics in CVD;
  • Emerging pharmacological and non-pharmacological interventions;
  • Sex- and gender-related differences in cardiovascular disease;
  • Multisystem Interactions and Comorbidities: cardiorenal syndrome, cardiometabolic and cardiohepatic syndromes, cardio-oncology and systemic diseases affecting cardiac function;
  • Digital tools, machine learning and AI in cardiology.

Keywords: Cardiac and circulatory diseases; multisystem Interactions and Comorbidities; molecular mechanisms; cardiac imaging; novel therapies; regenerative medicine; health technologies.

Deadline for manuscript submissions: 31 May 2026

Submission link:

All manuscripts will undergo rigorous peer review. Please let me know if you are interested, or feel free to submit your manuscript directly via the journal’s system.

Thank you for considering this invitation, and we look forward to receiving your contributions.

Warm regards,

Dr. Shuai Guo
Prof. Dr. Aleksandar Jovanovic
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac and circulatory diseases
  • multisystem interactions and comorbidities
  • molecular mechanisms
  • cardiac imaging
  • novel therapies
  • regenerative medicine
  • health technologies

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Published Papers (1 paper)

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Research

14 pages, 695 KB  
Article
Improving Endothelium-Dependent Vasodilation with Dietary Intake of n-3 Polyunsaturated Fatty Acids-Enriched Chicken Meat: A Randomized Controlled Trial
by Tihana Nađ, Martina Kos, Ana Stupin, Ines Drenjančević, Nikolina Kolobarić, Zrinka Mihaljević, Petar Šušnjara, Mia Damašek, Darjan Kardum and Ivana Jukić
Biomedicines 2026, 14(4), 852; https://doi.org/10.3390/biomedicines14040852 - 8 Apr 2026
Viewed by 571
Abstract
Objective: Vascular function serves as an early indicator of cardiovascular (CV) risk. The intake of n-3 polyunsaturated fatty acids (PUFAs) has been reported to improve arterial properties and reduce CV risk, but evidence in healthy individuals remains limited. This study investigated the effects [...] Read more.
Objective: Vascular function serves as an early indicator of cardiovascular (CV) risk. The intake of n-3 polyunsaturated fatty acids (PUFAs) has been reported to improve arterial properties and reduce CV risk, but evidence in healthy individuals remains limited. This study investigated the effects of consuming n-3 PUFAs-enriched chicken meat on vascular reactivity at both microvascular and macrovascular levels in healthy young adults. Materials and Methods: In this placebo-controlled, double-blind, randomized interventional trial (ClinicalTrials.gov: NCT05725486), 39 participants (aged 20–26 years) were assigned to either the Control group (n = 20; approximately 118 mg n-3 PUFAs/day) or the n-3 PUFA group (n = 19; approximately 1500 mg n-3 PUFAs/day) for three weeks. Microvascular reactivity was assessed via post-occlusive reactive hyperemia (PORH), acetylcholine-induced dilation (AChID), local thermal hyperemia (LTH), and sodium nitroprusside-induced (SNPID) responses. Macrovascular reactivity was measured by brachial artery flow-mediated dilation (FMD) and nitroglycerine-mediated dilation (NTG-MD). Body composition and blood pressure (BP) were recorded before and after the intervention. Results: Both microvascular (PORH, AChID, and LTH) and macrovascular (FMD) endothelium-dependent vasodilation increased in the n-3 PUFAs group following the dietary protocol compared to the Control group. Conversely, the three-week dietary intervention did not influence endothelium-independent dilation in either the microvasculature (SNPID) or macrovasculature (NTG-MD) within the groups compared to baseline, nor were any differences observed between the groups. No significant changes were noted in BP or body composition after either diet. Conclusions: In healthy young adults, consuming the n-3 PUFAs-enriched chicken meat for three weeks improved endothelium-dependent vasodilation in both micro- and macrocirculation, without affecting endothelium-independent responses. These findings suggest that dietary n-3 PUFA intake may provide vascular benefits even in healthy, disease-free individuals at rest. Full article
(This article belongs to the Special Issue Advances in Cardiovascular Disease: Mechanisms and Treatments)
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