Recent Advances in Circadian Rhythms

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 893

Editors


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Guest Editor
Faculty of Dental Medicine and Health, University J. J. Strossmayer Osijek, 31000 Osijek, Croatia
Interests: mental health; cardiogenetics; genetic epidemiology; circadian rhythm; molecular biology research
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Guest Editor
1. Department of Medica l Statistics, Epidemiology and Medical Informatics, School of Public Health Andrija Štampar, 10000 Zagreb, Croatia
2. School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Interests: mental health; cardiogenetics; genetic epidemiology; circadian rhythm; molecular biology research

Special Issue Information

Dear Colleagues,

Circadian rhythms have been shown to regulate various biological processes in multiple species, influencing sleep–wake cycles, hormone secretion, metabolism, immune functions, and behavior. Disruption of these rhythms has been linked to various diseases, including metabolic syndrome, neurodegenerative diseases, cancer, and psychiatric disorders.

This Special Issue of Biomedicines welcomes contributions of original articles that address molecular and genetic regulation of the circadian clock, chronobiology in health and disease, environmental factors influencing circadian adaptation, chronotherapeutics, time-based treatment strategies, computational modeling and systems biology approaches, and technological innovations in circadian monitoring and manipulation.

The primary objective of this Special Issue is to advance our understanding of the bidirectional relationship between circadian rhythmicity and human health, bridging fundamental mechanisms with clinical applications and filling the knowledge gap. This issue will serve as a platform for interdisciplinary discourse, fostering a deeper appreciation for how chronobiology can inform both the etiology of disease and the development of novel therapeutic strategies. This issue aims to gather contributions from various disciplines, including molecular biology, neuroscience, clinical medicine, and bioengineering.

We cordially invite researchers from around the globe to submit high-impact contributions to this Special Issue. We particularly encourage submissions of original research articles, insightful reviews, and concise communications that report on novel mechanisms, advanced methodologies, and translational findings.

Dr. Ivana Škrlec
Dr. Zrinka Biloglav
Guest Editors

Manuscript Submission Information

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Keywords

  • circadian rhythms
  • biological clocks
  • chronobiology
  • sleep–wake regulation
  • clock genes
  • chronotherapy
  • temporal physiology
  • circadian misalignment
  • molecular chronobiology
  • circadian biomarkers

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Published Papers (1 paper)

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Research

24 pages, 3038 KB  
Article
Circadian Disruption Exacerbates Innate Immune Responses by Modulating the Bistability of Pro-Inflammatory Signaling: A Dynamical Modeling Study
by Quan Zhou, Qi Ouyang and Hongli Wang
Biomedicines 2026, 14(7), 1454; https://doi.org/10.3390/biomedicines14071454 - 26 Jun 2026
Viewed by 321
Abstract
Background/Objectives: Circadian disruption resulting from factors such as jet lag, shift work, or aging leads to exaggerated inflammatory responses and increased disease susceptibility. However, the core dynamical mechanism by which circadian disruption exacerbates innate immune responses remains poorly understood. Methods: We develop an [...] Read more.
Background/Objectives: Circadian disruption resulting from factors such as jet lag, shift work, or aging leads to exaggerated inflammatory responses and increased disease susceptibility. However, the core dynamical mechanism by which circadian disruption exacerbates innate immune responses remains poorly understood. Methods: We develop an integrated mathematical model coupling the mammalian circadian clock with antigen-induced innate immune responses, incorporating key regulatory interactions including glucocorticoid modulation and pro-inflammatory positive feedback loops. Results: The model successfully recapitulates experimental data regarding homeostatic immune circadian oscillations and time-dependent gating of acute inflammatory responses. Dynamic analyses reveal that the circadian clock exerts its gating function by modulating the bistable characteristics within pro-inflammatory positive feedback loops. Circadian disruption, simulated as jet lag or age-related reduction in clock gene amplitude, reshapes this bistable landscape and prolongs residence duration in the pathological hyperinflammatory state. Conclusions: This shift not only amplifies acute cytokine bursts but also sustains exaggerated inflammatory activity, providing a mechanistic explanation for acute tissue injury and chronic low-grade inflammation (inflammaging) under these circadian disruption scenarios. Full article
(This article belongs to the Special Issue Recent Advances in Circadian Rhythms)
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