Immunometabolism in Cancer and Autoimmunity: Mechanisms and Therapeutic Targeting
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 48
Special Issue Editor
Interests: chemoprevention; resolution of inflammation; cancer immunology; autoimmune disease
Special Issue Information
Dear Colleagues,
Metabolism has emerged as a critical regulator of immune cells, including T cells, B cells, dendritic cells, and macrophages. Precise metabolic control maintains immune homeostasis, while disruptions can contribute to disease pathogenesis, such as cancer and autoimmune disorders. Immunometabolism covers fundamental cellular processes such as nutrient sensing, nutrient transport into cells, biochemical reactions that generate energy, and biomolecules in immune cells. It governs organelle dynamics, redox balance and ROS signaling, epigenetic modifications, and post-translational modifications, thereby integrating multiple cellular processes to coordinate immune responses through signaling pathways. Advances in immunometabolism research are creating new opportunities for the development of therapeutic strategies.
This Special Issue will explore the mechanisms and consequences of metabolic regulation in immune cells in cancer and autoimmune diseases. We welcome studies on nutrient sensing, metabolic reprogramming, organelle dynamics, redox balance, and epigenetic and post-translational regulation, particularly in the context of signaling pathway modulation or potential for metabolic interventions. Studies on tumor–immune metabolic crosstalk are also encouraged. By linking perspectives from immunology, metabolism, and disease pathology, this issue aims to advance our understanding of how metabolic pathways maintain immune homeostasis, how their disruption drives disease, and how these insights can inspire innovative therapeutic approaches.
Dr. Xiancai Zhong
Guest Editor
Manuscript Submission Information
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Keywords
- immunometabolism
- cancer
- autoimmunity
- metabolic reprogramming
- nutrient sensing
- organelle dynamics
- metabolic interventions
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