Mitochondrial Dysfunction in Health and Disease: Implications for Cellular Metabolism and Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 29
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria are integral to cellular function, playing a critical role in energy production, cell survival, and metabolic regulation. Mitochondrial dysfunction, characterized by impaired ATP synthesis, elevated reactive oxygen species (ROS) production, mitochondrial DNA (mtDNA) mutations, and defective mitophagy, has emerged as a hallmark of numerous diseases. Recent advances in high-resolution imaging, single-cell multi-omics, and CRISPR-based gene editing have deepened our mechanistic understanding of how mitochondrial dysfunction perturbs cellular metabolism, yet translation into effective therapies remains challenging.
This Special Issue aims to compile cutting-edge research and comprehensive reviews on the mechanisms and consequences of mitochondrial dysfunction across diverse disease contexts, including (but are not limited to) the following:
- Molecular mechanisms of mitochondrial quality control (mitophagy, dynamics, biogenesis) in metabolic disorders.
- Crosstalk between mitochondrial dysfunction, redox signaling, and inflammatory pathways.
- Mitochondrial-targeted antioxidants, metabolic modulators, and gene therapy strategies.
- Novel biomarkers (metabolomic, proteomic, epigenomic) for early detection of mitochondrial disease.
- Comparative studies of mitochondrial metabolism across disease models.
I look forward to receiving your contributions.
Dr. Chellakkan S. Blesson
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- metabolic reprogramming
- cellular metabolism
- ROS
- mitochondrial dynamics
- mitochondrial dysfunction
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