Selective Vulnerability in Neurodegenerative Diseases

Dear Colleagues,

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are widely thought to be caused by misfolding, and eventually aggregation, of proteins that are widely expressed in the central nervous system.  For poorly understood reasons, neurodegenerative diseases tend to target specific brain regions but leave others relatively unscathed, a feature known as selective vulnerability. If we can determine how resistant regions avoid disease, transferring their secrets to vulnerable regions may slow disease progression.

I am pleased to invite you to submit an article to this Special Issue on “Selective Vulnerability in

Neurodegenerative Diseases”. Articles may be focused at the cellular, regional, or network levels, but exploration of multiple levels is highly desired. Critical comparisons of human diseases and the related cell and animal models are also desired. Any neurodegenerative disease involving protein misfolding, including Alzheimer’s, Parkinson’s, Huntington’s and related polyglutamine diseases, prion diseases, tauopathies, synucleinopathies, amyotrophic lateral sclerosis, etc., may be included. 

This Special Issue aims to consolidate what is currently known about selective vulnerability, what remains to be learned, and what technical or experimental barriers are holding us back. In this Special Issue, original research and review articles are welcome. Research areas may include (but are not limited to) in vivo imaging, neuropathology, behavior, genomics, proteomics, transcriptomics, and modelling. I look forward to receiving your contributions.

Sincerely,

Dr. Walker Jackson
Guest Editor

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