Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease
Abstract
:Simple Summary
Abstract
1. Introduction
2. Tau Structure, Function, and Pathology
3. Selective Vulnerability in Sporadic AD
4. Tau PTM Processivity
5. Tau Transformation—Early Pathological Changes in Tau Localization, Conformation, and Structure
6. Tau Spreading and Seeding
7. When the Levee Breaks—Aging, Proteostatic Clearance, and Failing Quality Control
8. Concluding Remarks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Carroll, T.; Guha, S.; Nehrke, K.; Johnson, G.V.W. Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease. Biology 2021, 10, 1047. https://doi.org/10.3390/biology10101047
Carroll T, Guha S, Nehrke K, Johnson GVW. Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease. Biology. 2021; 10(10):1047. https://doi.org/10.3390/biology10101047
Chicago/Turabian StyleCarroll, Trae, Sanjib Guha, Keith Nehrke, and Gail V. W. Johnson. 2021. "Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease" Biology 10, no. 10: 1047. https://doi.org/10.3390/biology10101047