Cancer Signaling Pathways, Crosstalk and Therapeutics

Dear Colleagues,

Cancer is a major problem of disease worldwide and, each year, many millions of people are diagnosed with cancer around the world, and more than half of them die. Cancer ranks second, next to cardiovascular diseases, for causing the greatest number of deaths. Therefore, it is important to study cancer in depth. Cell death is an essential biological process in maintaining homeostasis, as well as in removing dead cells. Both cell growth and cell death are important mechanisms for cancer proliferation, development and for chemoresistance. Both mechanisms are complex, however, apoptosis, autophagy, necrosis, or necroptosis signaling cascade plays a crucial role. Moreover, tumor microenvironment has a significant impact on cell proliferation, death, metabolism and chemotherapy. Therefore, it is vital to consider all of these factors for chemotherapy. This Special Issue focuses on “Cancer Signaling Pathways, Crosstalk and Therapeutics”. The main objectives are not restricted to apoptosis, necrosis, autophagy, ferroptosis or lysosomal signaling cascade but also target various pathways for tumor annihilation, cell death for intrinsic and extrinsic apoptosis, novel plants, chemical drugs, nanomedicine or strategies targeting cancer promoting proteins (BH3, SMAC mimetics, cFLIP, XIAP).

This Special Issue welcomes the submission of original research and review articles focusing on cancer signaling pathways and therapeutics; however, research on new technologies employed for studying cancer biomarker identification, tracing cancer pathways, that will help us to understand cancer biology in depth is also welcome. This Special Issue will enlighten readers about new discoveries, advances, and development in cancer therapeutics.

Dr. Imran Khan
Dr. Faisal Aziz
Guest Editors

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