Regulation of p53 Function by Long Non-Coding RNAs
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 342
Special Issue Editor
Special Issue Information
Dear Colleagues,
Depending on the annotation method, recent estimations indicate that the human genome encodes for 15,000–100,000 long noncoding RNA (lncRNA) genes, which therefore represent a large class of transcripts, most probably outnumbering protein-coding mRNAs. The physiological functions of the large majority of these transcripts are not well characterized, and there is debate as to whether or not many lncRNAs may represent non-functional transcriptional noise. While lncRNA functionality, in many instances, may reflect transcriptional activity at a specific regulatory genomic locus that is independent of the lncRNA sequence itself, sequence-specified functions, including the scaffolding of proteins and other RNAs, or protein and RNA decoy activity, have been demonstrated for a number of lncRNAs. Moreover, altered lncRNA expression or function has been implicated in numerous human diseases. The p53 transcription factor activates many target genes that mediate its tumor suppressive functions, among them, the induction of cell cycle arrest and apoptosis. A growing number of lncRNAs have been shown to be direct transcriptional targets and downstream effectors of p53, some of which are involved in positive or negative feedback-regulation to p53. Likewise, several lncRNAs regulate p53 signaling independent from direct activation by p53.
For this Special Issue of Biology, we invite authors to submit original research papers and reviews that cover recent progress in areas related to the “Regulation of p53 function by long non-coding RNAs”.
Dr. Markus Kaller
Guest Editor
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Keywords
- P53
- lncRNA
- transcription
- tumor suppression
- feedback-regulation
- ceRNA
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