Special Issue "Regulation of p53 function by long non-coding RNAs"

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 January 2021.

Special Issue Editor

Dr. Markus Kaller
Guest Editor
Institute of Pathology, Ludwig-Maximilians-University Munich, Germany
Interests: p53, lncRNAs, miRNAs, gene expression, transcription factors, EMT, colorectal cancer

Special Issue Information

Dear Colleagues,

Depending on the annotation method, recent estimations indicate that the human genome encodes for 15,000–100,000 long noncoding RNA (lncRNA) genes, which therefore represent a large class of transcripts, most probably outnumbering protein-coding mRNAs. The physiological functions of the large majority of these transcripts are not well characterized, and there is debate as to whether or not many lncRNAs may represent non-functional transcriptional noise. While lncRNA functionality, in many instances, may reflect transcriptional activity at a specific regulatory genomic locus that is independent of the lncRNA sequence itself, sequence-specified functions, including the scaffolding of proteins and other RNAs, or protein and RNA decoy activity, have been demonstrated for a number of lncRNAs. Moreover, altered lncRNA expression or function has been implicated in numerous human diseases. The p53 transcription factor activates many target genes that mediate its tumor suppressive functions, among them, the induction of cell cycle arrest and apoptosis. A growing number of lncRNAs have been shown to be direct transcriptional targets and downstream effectors of p53, some of which are involved in positive or negative feedback-regulation to p53. Likewise, several lncRNAs regulate p53 signaling independent from direct activation by p53. For this Special Issue of Biology, we invite authors to submit original research papers and reviews that cover recent progress in areas related to the “Regulation of p53 function by long non-coding RNAs”.

Dr. Markus Kaller
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • P53
  • lncRNA
  • transcription
  • tumor suppression
  • feedback-regulation
  • ceRNA

Published Papers

This special issue is now open for submission.
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