Role and Function of GSK-3 in the Regulation of Immunity
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: closed (28 December 2021) | Viewed by 4802
Special Issue Editors
Interests: GSK-3; T cells; immunotherapy; immune checkpoint blockade; signaling; cancer
Special Issue Information
Dear Colleagues,
Glycogen Synthase kinase (GSK)-3 is a multifunctional serine/threonine kinase implicated in several disease states and key cellular processes, including Wnt, insulin and Hedgehog signalling. There are two paralogs of GSK-3 and together they are known to phosphorylate over 100 substrates yet much of the mechanism/s behind GSK-3 regulation remains to be fully elucidated.
GSK-3 has been found to play a key role in diabetes, Alzheimer disease, inflammation and cancer, and there are studies in which the inactivation of GSK-3 can have a positive effect in these diseases. A classic inhibitor of GSK-3; lithium Chloride, has been used for decades as a mood stabiliser to treat bipolar disorder, however further inhibitors of GSK-3 have struggled to pass clinical trials due to issues around toxicity. This may be due to inhibitor specificity or more likely the many other pathways GSK-3 may be affecting alongside that desired. Specific targeting of GSK-3 whether it be in specific cells/ tissue or one of the paralogs of GSK-3 will not only advance our knowledge in this area but may lead to the development of new and/or improved immunotherapies.
This Special Issue welcomes the submission of original research and review manuscripts on all aspects of GSK-3 function in the immune response, covering mechanisms by which GSK-3 may control disease, roles for the two paralogs and the possible targeting and application of GSK-3 in immunotherapies, to bring together current ideas and opinions about this extraordinary kinase, discuss what remains to be discovered and stimulate the emergence of new ideas to develop the advancement/generation of new therapeutic approaches.
Dr. Alison Taylor
Dr. Anke Brüning-Richardson
Guest Editors
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Keywords
- GSK-3
- T cells
- Immunotherapy
- immune checkpoint blockade
- signaling
- cancer
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