Special Issue "Natural Products in Modern Biology: Ancient Wisdom for Today‘s Challenges"

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editors

Dr. Marcus Krüger
Website
Guest Editor
Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany
Interests: cancer biology; cancer treatment; tissue engineering; microgravity; chlorophyll; antimicrobial resistance; photodynamic therapy
Dr. Peter Richter
Website
Guest Editor
Department of Biology, Friedrich-Alexander University Erlangen-Nürnberg, Germany
Interests: cell biology; plant physiology; photodynamic therapy
Special Issues and Collections in MDPI journals
Dr. Sebastian M. Strauch
Website
Guest Editor
Postgraduate Program in Health and Environment, University of the Region of Joinville - Univille, Rua Paulo Malschitzki 10, Joinville 89219–710, Brazil
Interests: Chlorophyll, Gravitational biology, Phytoplankton, Photodynamic therapy

Special Issue Information

Dear Colleagues,

The use and exploitation of natural products (NPs) is anchored throughout the history of mankind. Today, the modern tools of biology (bioinformatics, proteomics, genomics, metagenomics, structural biology, and analytical technologies) allow scientists to understand the biological effects of natural compounds on cells, organisms, and the human body. NPs have evolved their function over millions of years making them often more efficient than synthetic substances if a specific biological activity is needed. The discovery of penicillin by Alexander Fleming or the discovery of streptomycin by Selman A. Waksman, were not only history-changing milestones that greatly affect human life, but also heralded a ‘Golden Age’ of NP-based drug discovery. During the last years, antimicrobial photodynamic therapy using NPs has become an effective way in the control of pathogenic bacteria, and curcumin holds much promise for the development of new therapies against cancer and other diseases.

Taken together, the complex NPs represent an eminent source of novel lead compounds, in particular for antibiotics and antiproliferative agents, and maybe only a very small part of this ‘gold mine’ had just been discovered. With continuing insights into the molecular basis of various diseases (in different organisms), more approaches for NP-based therapies will be created. Innovative strategies in drug discovery are of great importance to meet today’s global health challenges such as the rise of drug-resistant pathogens, increasing cancer incidence or the growing prevalence of other diseases.

This Special Issue welcomes the submission of original research, short communications, and review manuscripts focusing on the biological effects of natural products, especially in therapy approaches (not restricted to humans), but also on the specific technologies employed in their identification and targeting, helping us to provide a realistic overview of this very exciting and interdisciplinary field of biological research.

Dr. Marcus Krüger
Dr. Peter Richter
Dr. Sebastian M. Strauch
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antimicrobials
  • Cancer Treatment
  • Immunomodulators
  • Antimutagens
  • Neuroprotective Agents
  • Photodynamic Therapy
  • Bioactive Substances
  • Pharmaceutical Biology
  • Pharmacognosy
  • Plant Protection

Published Papers (1 paper)

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Research

Open AccessArticle
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin
Biology 2020, 9(6), 114; https://doi.org/10.3390/biology9060114 (registering DOI) - 30 May 2020
Abstract
Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed [...] Read more.
Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed using different physical methods. The anti-inflammatory activity was evaluated in vivo by ear edema, paw edema, cotton pellet-induced granuloma, and vascular permeability by Evans blue extravasation. The mechanism of action was validated by molecular docking of the major constituent into the cyclooxygenase-2 (COX-2 enzyme). All doses of the COEFC reduced acute paw edema induced by carrageenan and dextran, as well as vascular permeability. Our results suggest the lowest effective dose of all samples inhibited the response induced by histamine or arachidonic acid as well as the granuloma formation. The complexation process showed that the pharmacological effects were maintained, however, showing similar results using much lower doses. The results demonstrated an involvement of the inhibition of pathways dependent on eicosanoids and histamine. Complexation of β-cyclodextrin/Essential oil (β-CD/EO) may present an important tool in the study of new compounds for the development of anti-inflammatory drugs. Full article
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