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Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats

Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania
Institute of Research and Development in Technical and Natural Sciences, Aurel Vlaicu University, 310025 Arad, Romania
Faculty of Pharmacy, Vasile Goldis Western University of Arad, 310025 Arad, Romania
Advanced Research and Development Center for Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700454 Iasi, Romania
Author to whom correspondence should be addressed.
Biology 2021, 10(1), 43;
Received: 14 December 2020 / Revised: 4 January 2021 / Accepted: 8 January 2021 / Published: 11 January 2021
Diabetes mellitus is a metabolic condition that affects millions of people globally. The present study highlights the enhanced activity of flaxseed lignans and polyphenols isolated from Linum usitatissimum in streptozotocin (STZ)-induced diabetic rats. Treatment with flaxseed extract showed enhanced glycosylated hemoglobin and blood glucose levels and reduced plasma cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides, urea and uric acid intensities, and plasma creatinine in the treated diabetic experimental animals, indicating beneficial effects—results sustained by histopathological observations of liver, pancreas, kidney, and spleen. Translation of this nutraceutical-based approach still requires further elucidation of its mechanism of action toward clinical applications.
Flaxseeds play an important role in human health due to their chemical composition and recognized beneficial outcomes. This study investigated the antidiabetic effects of present lignans and polyphenols found in the flaxseed extract on streptozotocin (STZ)-induced diabetic rats. The flaxseed administration produced favorable changes in body weight, food and water intake, and glycosylated hemoglobin and blood glucose quantities in the treated diabetic rats. Additionally, significant positive results were observed in the biochemical parameters, namely reduced plasma cholesterol, LDL cholesterol and triglycerides, plasma creatinine, and urea and uric acid levels, highlighting the seeds’ use in traditional medicine. The results were sustained by histopathological observations that showed better tissue preservation following the flaxseed diet. Overall, the consumption of flaxseeds produced moderate reduction in glucose levels and hyperlipidemia, together with improvement in the impaired organs’ function in diabetic rats. The daily administration of polyphenols and lignans compounds could impact therapeutic potential in diabetes management. View Full-Text
Keywords: lignans; polyphenols; flaxseed extract; streptozotocin; antidiabetic effects lignans; polyphenols; flaxseed extract; streptozotocin; antidiabetic effects
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MDPI and ACS Style

Draganescu, D.; Andritoiu, C.; Hritcu, D.; Dodi, G.; Popa, M.I. Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats. Biology 2021, 10, 43.

AMA Style

Draganescu D, Andritoiu C, Hritcu D, Dodi G, Popa MI. Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats. Biology. 2021; 10(1):43.

Chicago/Turabian Style

Draganescu, Dan, Calin Andritoiu, Doina Hritcu, Gianina Dodi, and Marcel Ionel Popa. 2021. "Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats" Biology 10, no. 1: 43.

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