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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mathematical Models for Medical Diagnosis and Testing

edited by

Peiyuan Zhou

and

Andrew K. C. Wong

submission deadline 28 Feb 2026 | 7 articles | Viewed by 13865 | Submission Open

Keywords: mathematical modeling; machine learning; artificial intelligence; pattern discovery; medical diagnosis; clinical data analysis; predictive analytics; explainable AI; statistical modeling; anomaly detection; rare disease detection; knowledge discovery; health informatics

(This special issue belongs to the Section Biosignal Processing)

Advances and Innovations in Wound Repair and Regeneration

edited by

Shiva Akbarzadeh

and

Azam Ali

submission deadline 28 Feb 2026 | 7 articles | Viewed by 13268 | Submission Open

Keywords: engineered skin graft; three-dimensional skin printing; skin grafting in animal models; dermal substitutes

(This special issue belongs to the Section Regenerative Engineering)

Deciphering Medicine: The Role of Explainable Artificial Intelligence in Healthcare Innovations, 2nd Edition

edited by

Mohamed Shehata

and

Mostafa Elhosseini

submission deadline 28 Feb 2026 | 4 articles | Viewed by 13171 | Submission Open

Keywords: deciphering medicine; explainable AI; machine learning; deep learning; medical diagnostics and treatment

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence-Based Medical Imaging Processing

edited by Xin Meng and Yuxiang Zhou

submission deadline 28 Feb 2026 | 10 articles | Viewed by 12384 | Submission Open

Keywords: artificial intelligence; medical imaging; disease detection and prediction; quantitative analysis; clinical integration; bias resilience; model transparency; precision medicine

(This special issue belongs to the Section Biosignal Processing)

Intelligent Wearable and Implantable Devices for Biomedical Applications

edited by Milad Zamani and

Dante Mantini

submission deadline 28 Feb 2026 | 4 articles | Viewed by 9912 | Submission Open

Keywords: bio-inspired and neuromorphic computation; spiking neural networks; biosensor devices and interface circuits; bioelectronics; biosensors; biotelemetry

(This special issue belongs to the Section Biosignal Processing)

New Sights of EEG and Brain Diseases: Updates and Directions

edited by

Carlos Trenado

and Christian Penaloza

submission deadline 28 Feb 2026 | 3 articles | Viewed by 9762 | Submission Open

Keywords: EEG; brain diseases; neuropsychiatric conditions; prosthetics

(This special issue belongs to the Section Biosignal Processing)

Modern Medical Imaging in Disease Diagnosis Applications

edited by Carlo Cosimo Quattrocchi and

Marco Parillo

submission deadline 28 Feb 2026 | 2 articles | Viewed by 8708 | Submission Open

Keywords: radiology; diagnostic imaging; contrast media; computed tomography; magnetic resonance imaging; ultrasound; artificial intelligence in medical imaging; radiomics

(This special issue belongs to the Section Biosignal Processing)

Engineering Microalgal Systems for a Greener Future

edited by

Ana Filipa Cruz Esteves

and

Alok Kumar Patel

submission deadline 28 Feb 2026 | 4 articles | Viewed by 8323 | Submission Open

Keywords: artificial intelligence; machine learning; bioprocessing; circular bioeconomy; production value addition; biomass valorization; microalgal cultivation systems; sustainable bioprocessing

(This special issue belongs to the Section Biochemical Engineering)

Deep Learning in Medical Applications: Challenges and Opportunities

edited by Richard Bayford,

Sikandar Ali

and

Ali Hussain

submission deadline 28 Feb 2026 | 2 articles | Viewed by 8068 | Submission Open

Keywords: deep learning; medical imaging; healthcare; artificial intelligence

(This special issue belongs to the Section Biosignal Processing)

Cutting-Edge Applications of Machine and Deep Learning in Biomedical Signal and Image Processing

edited by

Pedro Miguel Rodrigues

, Bruno Bispo and Joaquim Celestino

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7522 | Submission Open

Keywords: biosignal analysis; medical image analysis; machine learning; deep learning; wearable bio-technology

(This special issue belongs to the Section Biosignal Processing)

Biomaterials and Technology for Oral and Dental Health

edited by

Gherlone Felice Enrico

and

Giulia Teté

submission deadline 28 Feb 2026 | 3 articles | Viewed by 6413 | Submission Open

Keywords: biomaterials; odontoiatria; oral and dental health

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Progress in Stem Cells and Stem Cell-Derived Biotherapeutics for Regenerative Medicine Applications

edited by

Johnson Rajasingh

and Arghya Paul

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6044 | Submission Open

Keywords: stem cells; extracellular vesicles; exosomes; regenerative medicine; induced pluripotent stem cells; disease model; mesenchymal stem cells

(This special issue belongs to the Section Regenerative Engineering)

Recent Progress in Craniofacial Regeneration

edited by

Chengfei Zhang

and

Zhaoming Wu

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5979 | Submission Open

Keywords: craniofacial regeneration; regenerative medicine; tissue engineering; craniofacial stem cells; organoid; biomaterials

(This special issue belongs to the Section Regenerative Engineering)

Biomechanics and Mechanobiology in Cell and Tissue Engineering

edited by

Aaron Baker

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5966 | Submission Open

Keywords: biomechanics; mechanobiology; tissue engineering; cell engineering; vascular; cardiovascular; neuroengineering; stem cells; cancer; osteoarthritis; bone

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Insights in Tissue Engineering: Novel Developments, Current Challenges, and Future Perspectives

edited by

Philippe Abdel-Sayed

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5268 | Submission Open

Keywords: bioprinting; organ-on-chip; stem cells; vascularization; regeneration; tissue engineering; scaffold; biomaterials; organoids; ATMP

(This special issue belongs to the Section Regenerative Engineering)

Machine Learning and Artificial Intelligence in Pediatric Healthcare

edited by

Hammad Ashraf Ganatra

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3828 | Submission Open

Keywords: artificial intelligence; machine learning; pediatrics; natural language processing; diagnostics

(This special issue belongs to the Section Biosignal Processing)

IoT Technology in Bioengineering Applications: Second Edition

edited by Mihaela Hnatiuc and Larbi Boubchir

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3086 | Submission Open

Keywords: robotic device; signal processing; image processing; communication protocol; embedded system; smart sensors; cloud/FOG; predictive methods; monitoring; process optimization; diagnosis; implant; tele surgery; teleconsultation; telemonitoring

(This special issue belongs to the Section Biosignal Processing)

New Trends in Biomechanical Modeling in Musculoskeletal Disorders and Diseases

edited by

Philippe Gorce

submission deadline 28 Feb 2026 | 1 articles | Viewed by 3039 | Submission Open

Keywords: musculoskeletal disorders; musculoskeletal diseases; injury biomechanics; muscle biomechanics dynamic and kinematic modeling; gait and posture; muscle electromyography; motion analysis; postural control and balance; occupational health; occupational ergonomics; sport medicine; sport performance; quality of life

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Advanced 3D-Printed Biomaterials in Dentistry

edited by Andreas Zenthöfer and Ralf Erber

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2672 | Submission Open

Keywords: additive manufacturing; 3D printing; ceramics; polymer-based materials; bone substitutes

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Mechanobiology in Biomedical Engineering—2nd Edition

edited by Chun-Yuh Huang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2548 | Submission Open

Keywords: mechanobiology; stem cells; tissue engineering; cancer; bone; articular cartilage; intervertebral disk; chondrocytes; tumor microenvironment; organ fibrosis; mechanotransduction; muscle; skin; liver; kidney; heart; blood vessel; brain; nerve; periodontal ligament; tooth; dental tissue; mechanical force; organoids

(This special issue belongs to the Section Biomechanics and Sports Medicine)

The Next Generation of Tissue Engineering

edited by Tetsuya Imamura

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2127 | Submission Open

Keywords: tissue engineering; mesenchymal stem cells; engineered cell sheets; biofabricated cell structures

(This special issue belongs to the Section Regenerative Engineering)

Diagnostic Tools and Therapeutic Strategies for Hip Diseases

edited by Antonio Capone,

Giuseppe Marongiu

and

Lorenza Mattei

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1701 | Submission Open

Keywords: hip disease; coxarthrosis; arthritis; joint inflammatory disease; total hip arthroplasty; hip revision surgery; 3D printing; 3D modeling; advanced diagnostic imaging; tribology; finite element analysis

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Transcranial Direct Current Stimulation: Bridging Bioengineering and Neuroscience for Brain Health

edited by

Josué Fernández-Carnero

and

Víctor Navarro López

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1648 | Submission Open

Keywords: transcranial direct current stimulation (tDCS); neuroplasticity; neuromodulation

(This special issue belongs to the Section Biosignal Processing)

AI-Driven Approaches to Diseases Detection and Diagnosis

edited by Yannis Trakadis and

Antonio Brunetti

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1534 | Submission Open

Keywords: AI-driven diagnostics; disease detection; AI-driven treatment selection; precision medicine; +/− patient stratification; machine learning; deep learning; medical imaging; digital biomarkers; clinical decision support

(This special issue belongs to the Section Biosignal Processing)

Bioengineered Contact Lenses: Therapeutics, Biosensing, and Smart Interfaces

edited by

Ahmed Abass

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1327 | Submission Open

Keywords: contact lenses; vision correction; refractive error; smart contact lenses; drug delivery; biosensors; ocular physiology; corneal biomechanics; tear film; biocompatibility; biomedical engineering; responsive materials; wireless systems; myopia management and control; presbyopia; lens design; ocular surface; clinical applications; advanced manufacturing; digital health; mobile health apps

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Robotic-Assisted Rehabilitation

edited by

Hongwu Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1266 | Submission Open

Keywords: robotics-assisted rehabilitation; neurological rehabilitation robotics; wearable robotics; exoskeletons and assistive robotics; adaptive control in robotics; human– robot interaction; AI and machine learning in rehabilitation; translational studies in rehabilitation robotics; ethical considerations in rehabilitation robotics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advanced Restorative Dental Materials and Implant Technologies

edited by

Elena-Raluca Baciu

Alice Mirela Murariu

and

Gabriela Luminița Gelețu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1042 | Submission Open

Keywords: biomaterials; restorative dentistry; dental implants; patient specific implants; nanotechnology; guided tissue regeneration; digital dentistry; minimally invasive techniques; 3D printing

(This special issue belongs to the Section Regenerative Engineering)

Advancements and Innovations in Photoacoustic Imaging: Pioneering Techniques and Clinical Applications in Biomedical Research

edited by

Praveen Kumar Panangattukara Prabhakaran

Taeho Kim

and

Dong-Kwon Lim

submission deadline 28 Feb 2026 | 1 articles | Viewed by 964 | Submission Open

Keywords: tomography; deep tissue imaging; photoacoustic imaging; contrast agents; probes; nanoparticles; clinical applications; multimode imaging

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence in Dentistry: Innovations, Applications, and Future Perspectives, 2nd Edition

edited by

Hang Nga Mai

and

Tim Joda

submission deadline 28 Feb 2026 | 1 articles | Viewed by 920 | Submission Open

Keywords: artificial intelligence; big data in dentistry; explainable AI in dental diagnostics; blockchain in dental data security; natural language processing in dental records; robotics in dentistry; smart dental devices; AI in clinical decision support; automation in dentistry; AI-based diagnostic imaging; AI-supported treatment planning

(This special issue belongs to the Section Biosignal Processing)

Neuroimaging Techniques and Applications in Neuroscience

edited by

Md Nasir Uddin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 892 | Submission Open

Keywords: neuroimaging; brain; MRI; MR angiography; fMRI; PET; machine learning; artificial intelligence; neurological disorders

(This special issue belongs to the Section Biosignal Processing)

Advancements in Human–Machine Interaction and Robotics: From Biomechanics to Cognitive Neuroscience

edited by Jiejunyi Liang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 663 | Submission Open

Keywords: human-machine interaction; robotics; biomechanics; cognitive neuroscience; anthropomorphic robotic systems

Engineering with Nature: Bioengineering Innovations for the Environment and Nature-Based Solutions

edited by

Kristian L. Dubrawski

submission deadline 28 Feb 2026 | 1 articles | Viewed by 550 | Submission Open

Keywords: nature-based solutions; bioengineering; environmental sustainability; bioremediation; ecological engineering

(This special issue belongs to the Section Biochemical Engineering)

Advancing Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Through Computer-Aided Drug Design

edited by

Chin-Hung Lai

and

Suraj Narayan Mali

submission deadline 28 Feb 2026 | Viewed by 450 | Submission Open

Keywords: molecular docking; molecular dynamics; QSAR; AI; NSAIDs

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Artificial Intelligence (AI) in Bioengineering

edited by William C. Tang and Nathan Leroux

submission deadline 28 Feb 2026 | Viewed by 443 | Submission Open

Keywords: artificial intelligence; bioengineering; computational models; intelligent algorithms; biologically inspired systems; healthcare; diagnostics; personalized medicine; medical imaging analysis; biomedical signal processing; drug discovery and development; smart prosthetics and assistive technologies; clinical decision-making

(This special issue belongs to the Section Biosignal Processing)

Cognitive Decline and Its Transversality: Potential Mechanisms and Modulators of Disease

edited by

Cinzia Coppola

and

Elisabetta Signoriello

submission deadline 28 Feb 2026 | Viewed by 419 | Submission Open

Keywords: cognitive decline; Alzheimer’ s disease; fronto-temporal lobar degeneration; Lewy body disease; multiple sclerosis; protein misfolding; amyloid; tauopathy; neuroinflammation; microglia; astroglia; synaptopathy; CSF biomarkers; plasmatic biomarkers; micro-RNA or miRNA; long noncoding RNA or lncRNA; heart– brain axis; gut– brain axis; cerebrovascular disease; hippocampal atrophy; structural and functional neuroimaging

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

New Sights of Image Processing and Digital Models in Biomedicine

edited by Seyed Jalalddelin Mousavirad and

Diego Oliva

submission deadline 28 Feb 2026 | Viewed by 415 | Submission Open

Keywords: image processing and computer vision; deep learning; artificial intelligence; biomedicine

(This special issue belongs to the Section Biosignal Processing)

New Sight of Deep Learning in Bioengineering: Updates and Future Directions (2nd Edition)

edited by

Tao Zhang

submission deadline 28 Feb 2026 | Viewed by 322 | Submission Open

Keywords: deep learning; biomedicine; robotics and biomechanics; biomedical imaging; biosignal processing

(This special issue belongs to the Section Biosignal Processing)

Wearable Technologies and Health Informatics: Advancements in Bioengineering

edited by

Iqram Hussain

and

Jahowa Islam

submission deadline 28 Feb 2026 | Viewed by 301 | Submission Open

Keywords: wearable sensors; health monitoring; large language model; electronic health record; flexible sensors; sensors; artificial intelligence; smart healthcare; data privacy; machine learning; sensor applications; energy efficiency; health diagnostics; wearable signal processing (EEG; ECG; EMG; PPG; and IMU); internet of things (IoT); activity recognition; biomedical techniques; sleep medicine; smart grid; data science; smart surveillance

(This special issue belongs to the Section Biosignal Processing)

Wearable Sensors and Robotic-Assisted Technologies for Activity Assistance and Gait Rehabilitation

edited by

Chun-Ta Chen

and Xiaoling Hu

submission deadline 28 Feb 2026 | Viewed by 199 | Submission Open

Keywords: wearable sensors; robotic-assisted technology; activity assistance; gait rehabilitation; balance; movement impairment; exoskeleton robot

(This special issue belongs to the Section Biosignal Processing)

Advances in Soft Matter for Healthcare Applications

edited by

Ahmed Abass

submission deadline 28 Feb 2026 | Viewed by 198 | Submission Open

Keywords: soft matter; healthcare applications; hydrogels; drug delivery systems; flexible electronics; tissue engineering; soft robotics; bio-inspired materials; responsive materials; wearable sensors; biomedical devices; smart materials; thermally active materials; hot water bottles; pain management; biocompatible materials; clinical translation

Biofabrication of Biologically Realistic Constructs: Needs, Challenges, and Opportunities

edited by Nicanor Ilie Moldovan

submission deadline 28 Feb 2026 | Viewed by 167 | Submission Open

Keywords: biofabrication; biological realism; bioprinting; cell– biomaterial interaction; tissue engineering; hybrid constructs; clinical translation; in vitro models

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Bioengineering Approaches in Lung Injury and Repair

edited by

Antonio Matías Esquìnas

submission deadline 28 Feb 2026 | Viewed by 160 | Submission Open

Keywords: bioengineering; lung injury; repair mechanisms; stem cell therapy; biomaterials

(This special issue belongs to the Section Regenerative Engineering)

Multimodal AI‑Assisted Bioprinting: From Material Selection to Automated Fabrication

edited by Ewa Stodolak-Zych,

Ryszard Tadeusiewicz

and Kamila Rawojć

submission deadline 28 Feb 2026 | Viewed by 141 | Submission Open

Keywords: 3D bioprinting; artificial intelligence; machine learning; bioink design; tissue engineering; multimodal data; closed-loop fabrication; automated manufacturing

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Advanced Technologies for Orthopedic Repair and Regeneration

edited by Adriano Braile,

Mariantonia Braile

and Giuseppe Toro

submission deadline 28 Feb 2026 | Viewed by 140 | Submission Open

Keywords: orthopedic regeneration; 3D printing; bioactive materials; mesenchymal stem cells; smart biomaterials; tissue engineering; predictive modeling; immunoengineering; antimicrobial strategies; personalized implants

(This special issue belongs to the Section Regenerative Engineering)

Bioinformatics for Cardiovascular Disease

edited by João P. Monteiro and Quanyi Zhao

submission deadline 28 Feb 2026 | Viewed by 138 | Submission Open

Keywords: bioinformatics; cardiovascular disease; single-cell RNA-seq; single-cell ATAC-seq; spatial profiling; genomics; machine learning; multi-omics integration; systems biology; cardiac modeling; precision medicine; big data; translational bioinformatics

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Multiscale Mechanics of Biomaterials

edited by Pengfei Dong,

Linxia Gu

and Yi Hua

submission deadline 28 Feb 2026 | Viewed by 131 | Submission Open

Keywords: multiscale mechanics; atomic force microscopy; machine learning; biomaterials; finite element method

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Stem Cell Culture and Development of Tissue Engineered Models

edited by

Giuseppe Pettinato

submission deadline 28 Feb 2026 | Viewed by 127 | Submission Open

Keywords: stem cell culture; tissue engineering; organoids; biomaterials; 3D cell culture; regenerative medicine; disease modeling; organ-on-a-chip

(This special issue belongs to the Section Regenerative Engineering)

Big Data and Artificial Intelligence in Trauma Outcome Prediction

edited by Peter Fu Ming Hu, Shiming Yang and William Teeter

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: trauma triage; emergency medicine; clinical decision support; outcome prediction; precision medicine; artificial intelligence; natural language processing

(This special issue belongs to the Section Biosignal Processing)

Polymeric Biomaterials for Drug Delivery

edited by

Pere Dosta Pons

submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open

Keywords: biomaterials; polymeric nanoparticles; stimuli-responsive systems; biodegradable polymers; drug delivery; gene therapy; targeted delivery; controlled release

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

From 3D/4D Printing to Biofunctional Surfaces and Smart Implant Systems

edited by

Yuhe Yang

submission deadline 28 Feb 2026 | Viewed by 78 | Submission Open

Keywords: 3D/4D printing; biofunctional surfaces; smart implants; additive manufacturing in biomedicine

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

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