The Next Generation of Tissue Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 674

Special Issue Editor


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Guest Editor
Department of Urology, Shinshu University School of Medicine, Nagano 3908621, Japan
Interests: tissue engineering; biofabrication; mesenchymal stem cells; lower urinary tracts

Special Issue Information

Dear Colleagues,

The field of regenerative medicine promises to provide effective treatments, and its development relies on novel technologies for cells and biomaterials, which are crucial for aiding advances in regenerative engineering. In general, tissue engineering involves the practices of combining cells, scaffolds, and biologically active molecules to reconstruct functional tissues or organs. Expanding upon this technique, this Special Issue proposes next-generation tissue engineering, which supplements conventional concepts of tissue engineering with the use of microenvironments, regenerative fields, and the latest technologies. In addition, this Special Issue found that by using cell sheet technology and 3D bioprinting, cell structures biofabricated with mesenchymal stem cells, derived from bone marrow or adipose tissues and biomaterials, have great potential to reconstruct functional and histological tissues. These cell structures can significantly aid the restoration of injured tissues, as well increasing the activity of cells composed of these structures. Moreover, cell structures can be used in clinical practices such as minimally invasive surgery, easy handling, or certainty. In conclusion, this Special Issue argues that next-generation tissue engineering is able to form the foundation of regenerative engineering and can be used to develop regenerative medicine.

Dr. Tetsuya Imamura
Guest Editor

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Keywords

  • tissue engineering
  • mesenchymal stem cells
  • engineered cell sheets
  • biofabricated cell structures

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Published Papers (1 paper)

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Research

11 pages, 3112 KiB  
Article
Micron-Sized Fe3O4/PCL Biocomposite Scaffolds to Attract Magnetic Nanoparticles for Targeted Drug Delivery
by Jianhua Ge, Riley Drees, Aoran Wang, Bo Zhu and Shang-You Yang
Bioengineering 2025, 12(4), 371; https://doi.org/10.3390/bioengineering12040371 - 1 Apr 2025
Viewed by 383
Abstract
Adjuvant chemotherapy is a critical regime in cancer treatment. The magnetic targeted drug delivery system (MTDDS) can selectively aggregate chemotherapy agents at the target areas, which has attracted great attention due to its safety, high efficiency, and minimal side effects on the human [...] Read more.
Adjuvant chemotherapy is a critical regime in cancer treatment. The magnetic targeted drug delivery system (MTDDS) can selectively aggregate chemotherapy agents at the target areas, which has attracted great attention due to its safety, high efficiency, and minimal side effects on the human body. It would be ideal to establish a tissue engineering scaffold that can not only reconstruct the defect from the surgical tumor removal, but also serve as a magnetic station to attract MTDDS to the local site to enhance the targeted drug delivery. The current study constructed polycaprolactone magnetic tissue engineering scaffolds with various micrometer-sized magnets. The degradation properties of the scaffolds were assessed in simulated body fluid (SBF), and primary mouse bone marrow stromal cells were used to evaluate the biocompatibility of the scaffolds to osteoblast differentiations. The scaffolds were further examined by implantation to an air pouch model on the back of BALB/c mice. The in vitro data suggested that up to 40% of micron-sized magnetite can be used to formulate porous polycaprolactone (PCL) scaffolds with comparable biocompatibility to the PCL-alone scaffold. A mouse study revealed that the intro-peritoneal injected fluorescence-magnetic particles were collectedly enriched in the mouse air pouch tissues containing the 20% magnetic/PCL scaffolds. Histological assessment and the real-time PCR results of the air pouches confirmed the benign biocompatibility of the implanted magnetic scaffolds. Full article
(This article belongs to the Special Issue The Next Generation of Tissue Engineering)
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