Advanced Restorative Dental Materials and Implant Technologies

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 323

Special Issue Editors


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Guest Editor
Department of Implantology, Removable Dentures, Dental Technology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
Interests: dental alloys and polymers; properties of dental materials; innovations in biomaterials for restorative and prosthetic dentistry; additive manufacturing for custom dental solutions; virtual treatment planning
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Guest Editor
Department of Surgicals, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania
Interests: dental

E-Mail Website
Guest Editor
Department of Surgicals, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: dental implantology; oral surgery; advanced surgical techniques; ethics and decision-making in oncology; biomarkers for oral carcinoma diagnosis and prognosis; surgical management of oral and maxillof; custom made cranio-maxillofacial implants

Special Issue Information

Dear Colleagues,

Advancements in dental materials and technologies have revolutionized modern dentistry, providing improved solutions for complex dental conditions such as dental caries, periodontal diseases, and tooth loss. These innovations feature advanced materials and state-of-the-art techniques that enhance durability, biocompatibility, and aesthetics, along with custom-made implant technologies designed to ensure superior integration and long-term stability. This Special Issue aims to highlight the latest developments and applications of restorative dental materials and implant technologies in clinical and research contexts.

Researchers and practitioners from the fields of dental materials, restorative dentistry, prosthodontics, periodontics, and oral and orthognathic surgery are encouraged to contribute original research, clinical case studies, reviews, and meta-analyses that explore these advancements and their impact on improving patient care and oral health outcomes.

Dr. Elena-Raluca Baciu
Dr. Alice Mirela Murariu
Dr. Gabriela Luminița Gelețu
Guest Editors

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Keywords

  • biomaterials
  • restorative dentistry
  • dental implants
  • patient specific implants
  • nanotechnology
  • guided tissue regeneration
  • digital dentistry
  • minimally invasive techniques
  • 3D printing

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Published Papers (1 paper)

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Research

13 pages, 1300 KB  
Article
Can Preoperative Blood Inflammatory Biomarkers Predict Early Dental Implant Outcomes in Systemically Healthy Patients?
by Elena-Raluca Baciu, Cezara Andreea Onică, Gabriela Luminița Gelețu, Neculai Onică, Bogdan Florin Toma, Alexandra Cornelia Teodorescu, Costin Iulian Lupu and Alice Murariu
Bioengineering 2025, 12(11), 1208; https://doi.org/10.3390/bioengineering12111208 - 5 Nov 2025
Abstract
The aim of this study was to assess whether baseline the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII), and C-reactive protein (CRP) could predict postoperative outcomes in systemically healthy patients receiving dental implants. A retrospective analysis of 116 [...] Read more.
The aim of this study was to assess whether baseline the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII), and C-reactive protein (CRP) could predict postoperative outcomes in systemically healthy patients receiving dental implants. A retrospective analysis of 116 systemically healthy adults receiving dental implants was conducted. To minimise confounding, individuals over 50 years old, smokers, and those with systemic diseases, stage III/IV periodontitis, or current medication use were excluded. Periodontal status was classified as clinically healthy or stable. Baseline CRP and complete blood count-derived indices (NLR, PLR, SII) were recorded preoperatively. The primary outcome was osseointegration (proper versus impaired). Implant success was 95.7% (n = 111), with early implant failure occurring in 4.3% (n = 5). Females exhibited higher PLR values than males (p = 0.041), and SII was higher in periodontally stable patients compared to clinically healthy ones (p = 0.036). In systemically healthy patients, routine preoperative screening based on NLR, PLR, and CRP did not improve prediction of early implant failure, whereas SII demonstrated good, statistically significant discrimination (p = 0.015). These findings emphasise the need for further research to clarify the predictive value of blood inflammatory biomarkers. Full article
(This article belongs to the Special Issue Advanced Restorative Dental Materials and Implant Technologies)
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