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Bioengineering
Special Issues
Biomechanics and Mechanobiology in Cell and Tissue Engineering
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Biomechanics and Mechanobiology in Cell and Tissue Engineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 317

Special Issue Editor

Prof. Dr. Aaron Baker

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA
Interests: regenerative medicine; biomaterials; stem cells; mechanobiology; tissue engineering; vascular biology; cardiovascular disease; wound healing

Special Issue Information

Dear Colleagues,

This Special Issue, titled “Biomechanics and Mechanobiology in Cell and Tissue Engineering”, encompasses a comprehensive exploration of the diverse applications and implications of mechanobiology in various fields, including biology, medicine, and engineering. This Special Issue aims to delve into how physical forces influence biological processes and the mechanical properties that impact living organisms. This collection of original research articles and reviews focuses on the incorporation of mechanical cues into scaffold design, culture environments, and the development of innovative therapies and diagnostics. We welcome submissions from all therapeutic areas of tissue engineering, including, but not limited to, the following: vascular disease, cardiovascular disease, neurobiology and neuroengineering, stem cell mechanobiology, cancer mechanobiology, osteoarthritis, and bone mechanobiology.

Furthermore, we aim to highlight the crucial role played by mechanobiology research in bone and articular cartilage for the treatment of conditions such as osteoporosis and osteoarthritis. Additionally, this Special Issue emphasizes the significance of understanding how mechanical forces affect neuronal development, axon guidance, and neural regeneration for addressing neurodegenerative diseases and developing neural implants and tissue engineering approaches for spinal cord injuries. Furthermore, it underscores the influence of mechanobiology on drug discovery efforts, the identification of mechanosensitive drug targets, and the development of screening assays that incorporate mechanical cues. Overall, the interdisciplinary approach of this Special Issue means that it will provide valuable insights into the complex interactions between mechanical forces and biological systems, leading to advancements in healthcare, tissue engineering, and overall understanding of life processes.

Prof. Dr. Aaron Baker
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomechanics
  • mechanobiology
  • tissue engineering
  • cell engineering
  • vascular
  • cardiovascular
  • neuroengineering
  • stem cells
  • cancer
  • osteoarthritis
  • bone

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Published Papers (1 paper)

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Research

13 pages, 3265 KiB  
Article
A Pilot Study on the Age-Dependent, Biomechanical Properties of Longitudinal Ligaments in the Human Cervical Spine
by Narendra Singh, Ana Trajkovski, Jovan Trajkovski, Robert Kunc and Jose Felix Rodriguez Matas
Bioengineering 2025, 12(1), 61; https://doi.org/10.3390/bioengineering12010061 (registering DOI) - 13 Jan 2025
Viewed by 103
Abstract
The cervical spine ligaments, including the anterior longitudinal ligament (ALL) and posterior longitudinal ligament (PLL), play a key role in maintaining spinal stability by limiting excessive movements. This study investigates how ageing affects the mechanical properties of these ligaments. We analysed 33 samples [...] Read more.
The cervical spine ligaments, including the anterior longitudinal ligament (ALL) and posterior longitudinal ligament (PLL), play a key role in maintaining spinal stability by limiting excessive movements. This study investigates how ageing affects the mechanical properties of these ligaments. We analysed 33 samples from 12 human cervical spines (15 ALL, 18 PLL), averaging data from the same donors for independent analysis, resulting in 18 final samples (8 ALL, 10 PLL). To explore age-related changes, we classified the samples into two groups—below and above 50 years old—aligning with the peak incidence of major musculoskeletal disorders. The investigation concentrated on the effects of age on four mechanical parameters of the uniaxial stress–stretch curve: initial tangent stiffness (E0), maximum tangent stiffness (Em), ultimate stress (Pu) and ultimate stretch (λu). When the age effect is neglected, then the behaviours of both the ALL and PLL appeared similar. However, when introducing age as a variable into the context of the ALL and PLL, statistically significant differences became evident. The findings underscored a reduction in maximum tangent stiffness (p-value = 0.0147), ultimate stress (p-value = 0.0009), and ultimate stretch (p-value = 0.0024) when the ALL and PLL were grouped under and above 50 years as a consequence of ageing. Full article
(This article belongs to the Special Issue Biomechanics and Mechanobiology in Cell and Tissue Engineering)
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