Roles of Oxidative Stress in Human Pathophysiology

Dear Colleagues,

Oxidative stress, resulting from the imbalance between reactive oxygen/nitrogen species (ROS/RNS) and endogenous antioxidant defenses, plays a central role in shaping human pathology and pathophysiology. Due to constant pressure from endogenous and exogenous stressors (radiation, chemicals, pollution, microplastics, etc.), oxidative stress can contribute to molecular damage to DNA, proteins, and lipids, driving processes such as chronic inflammation, metabolic dysfunction, neurodegeneration, carcinogenesis, and loss of homeostasis. Understanding the dual nature of redox biology—as both a physiological regulator and a pathological trigger—remains a major challenge and an opportunity for therapeutic innovation.

This Special Issue of Antioxidants invites contributions that explore the diverse roles of oxidative stress across human diseases. We welcome original research articles, mechanistic studies, clinical investigations, and comprehensive reviews. Specific areas of interest include

1. Oxidative stress in cancer biology, cardiovascular and metabolic disorders, and neurodegenerative diseases;
2. Redox signaling and its dysregulation in human pathology;
3. Biomarkers of oxidative stress and antioxidant capacity in clinical practice;
4. Experimental and clinical evaluation of antioxidant therapies;
5. Crosstalk amongoxidative stress, inflammation, and immune response;
6. Translational and precision medicine approaches targeting redox balance.

By gathering cutting-edge research and perspectives, this Special Issue aims to advance our understanding of oxidative stress and foster new strategies for prevention, diagnosis, and treatment.

Prof. Dr. Alexandros Georgakilas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.