Enzyme Inhibitors: Recent Advances in the Anticancer Research
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 399
Special Issue Editors
Interests: medicinal chemistry; drug discovery; aromatase inhibitors; PPAR ligands; anticancer agents
Special Issues, Collections and Topics in MDPI journals
Interests: drug discovery; computational techniques; anticancer agents; aromatase inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The success of modulating enzyme activity as a strategy for drug development is evidenced by the fact that over 50% of commercially available drugs are composed of small molecules active on enzymes.
The involvement of enzymes in the critical stages of a disease's development makes them an ideal biological target for the design of molecules capable of docking sensitive ligand-binding sites.
Different enzymes are involved in the multiple pathogenetic mechanisms of cancer and, in recent years, there has been continuous progress in the development of therapeutic agents against the disease, including the identification of novel enzymatic targets and their inhibitors.
In this Special Issue, we focus our attention on new target-based anticancer agents that inhibit a specific enzyme involved in the development of cancer and in the control of chemoresistance.
We welcome the submission of research and review articles on the advances in the drug discovery, design, and development of enzyme inhibitors effective against various cancer models. Covered topics include the synthesis of novel compounds, the repurposing of old drugs, the use of natural compounds and drug metabolites, biological studies, and computational approaches.
This Special Issue aims to summarize the state of the art and the latest findings in the identification of suitable anticancer enzyme inhibitors, and to elucidate future directions.
Dr. Alessandra Ammazzalorso
Dr. Marialuigia Fantacuzzi
Guest Editors
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Keywords
- anticancer drugs
- cancer therapy
- drug discovery
- enzyme inhibitor
- synthesis
- structure–activity relationships
- natural compounds
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