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Antitumor Activity of Natural Products and Related Compounds—2nd Edition

Topic Information

Dear Colleagues,

Cancer is one of the leading causes of morbidity and mortality in humans today, and the number of people affected by cancer is growing. As a result, the search for new antitumor agents that may be more effective and secure than existing treatments is an ongoing effort.

Nature provides a wide range of compounds with a great variety of chemical scaffolds and distinct bioactivity profiles. Indeed, natural products are a rich source of bioactive molecules that, over the years, have found application in the treatment of many diseases, including cancer. Natural products have played an important role in chemotherapy and chemoprevention by providing antitumor drugs, such as camptothecin, doxorubicin, paclitaxel, vinblastine, and vincristine, as well as in understanding the cellular and molecular mechanisms underlying antitumor activity. Significant advances in natural source isolation and extraction techniques have enabled the identification of novel lead compounds as useful starting points for the generation of optimized molecules with enhanced therapeutic potential via semi-synthetic or synthetic processes.

The focus of this Topic is on natural substances derived from plants or animals, as well as their synthetic derivatives, which have been investigated for their ability to counteract cancer progression.

Dr. Barbara De Filippis
Dr. Alessandra Ammazzalorso
Dr. Marialuigia Fantacuzzi
Topic Editors

Keywords

  • anticancer
  • antiproliferation
  • natural compounds
  • natural derivatives
  • drug discovery
  • bioactive natural products
  • synthetic compounds
  • medicinal chemistry
  • computational chemistry
  • biological activity
  • structure–activity relationship
  • structure-based drug design
  • target identification and validation

Participating Journals

Biomolecules
Open Access
11,949 Articles
Launched in 2011
4.8Impact Factor
9.2CiteScore
19 DaysMedian Time to First Decision
Q1Highest JCR Category Ranking
Cancers
Open Access
33,663 Articles
Launched in 2009
4.4Impact Factor
8.8CiteScore
20 DaysMedian Time to First Decision
Q2Highest JCR Category Ranking
International Journal of Molecular Sciences
Open Access
103,917 Articles
Launched in 2000
4.9Impact Factor
9.0CiteScore
20 DaysMedian Time to First Decision
Q1Highest JCR Category Ranking
Molecules
Open Access
61,572 Articles
Launched in 1996
4.6Impact Factor
8.6CiteScore
16 DaysMedian Time to First Decision
Q2Highest JCR Category Ranking
Scientia Pharmaceutica
Open Access
1,558 Articles
Launched in 1930
2.5Impact Factor
4.6CiteScore
38 DaysMedian Time to First Decision
Q3Highest JCR Category Ranking
Pharmaceutics
Open Access
13,356 Articles
Launched in 2009
5.5Impact Factor
10.0CiteScore
15 DaysMedian Time to First Decision
Q1Highest JCR Category Ranking

Published Papers