Memory-Enhancing Activity of Bioactive Compounds: From Natural Sources to Brain, 2nd Edition

Dear Colleagues,

Memory and cognitive function play a fundamental role in daily life, influencing learning, decision-making, and overall well-being. However, various factors such as aging, stress, neurodegenerative diseases (e.g., Alzheimer’s and Parkinson’s disease), and environmental toxins can impair cognitive abilities, leading to memory decline. Given the increasing prevalence of cognitive disorders, there is a growing interest in discovering natural strategies to enhance memory and protect brain health.

Bioactive compounds derived from natural sources, including plants, herbs, probiotic bacteria, and dietary components, have shown promising neuroprotective effects. These compounds, such as polyphenols, alkaloids, terpenoids, and omega-3 fatty acids, exhibit antioxidant, anti-inflammatory, and neurotransmitter-modulating properties, which can improve memory and cognitive performance. Their mechanisms of action involve enhancing synaptic plasticity, stimulating neurogenesis, and protecting neurons from oxidative stress and inflammation.

The present Topic explores the potential of memory-enhancing bioactive compounds, highlighting their natural sources, mechanisms of action in the brain, and scientific evidence supporting their efficacy. Understanding these compounds may contribute to the development of nutraceuticals and therapeutic strategies for cognitive enhancement and neuroprotection.

Potential topics include, but are not limited to, the following:

• Neurobehavioral pharmacological studies;
• Neuroprotection (antioxidant and anti-inflammatory effects);
• Neurogenesis and synaptic plasticity;
• Neurotransmitter modulation;
• Meta-analysis of effectiveness;
• Gut–brain axis.

Prof. Dr. Lucian Hritcu
Dr. Simone Carradori
Topic Editors